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Gastrointestinal Stromal Tumor — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Morphology
Mesenchymal Cell Neoplasm
Stromal Neoplasm
Gastrointestinal Stromal Tumor

Subtype

Gastrointestinal Stromal Tumor

CI-CAN-00000918GISTExplore in graph →

Non-malignant49 active trials2 approved drugs89 evidence items

NCIt: C3868
OncoTree: GIST
DOID: 9253
UMLS CUI: C0238198
MeSH: D046152

Overview
Statistics
Survival
Genomics3
Variants & evidence89
Drugs8
Trials341
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (24)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 1–24 of 24 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor.
· J Clin Oncol · 2003 · PMID 14645423 · validated civic_curation pubmed
KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours.
· Eur J Cancer · 2006 · PMID 16624552 · validated civic_curation pubmed
Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study.
· Ann Oncol · 2019 · PMID 30624546 · validated civic_curation pubmed
PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.
· J Clin Oncol · 2005 · PMID 15928335 · validated civic_curation pubmed
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.
· J Clin Oncol · 2006 · PMID 16954519 · validated civic_curation pubmed
Efficacy of Imatinib in Patients with Platelet-Derived Growth Factor Receptor Alpha-Mutated Gastrointestinal Stromal Tumors.
· Cancer Res Treat · 2016 · PMID 26130666 · validated civic_curation pubmed
Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.
· J Clin Oncol · 2008 · PMID 18955451

Showing 1–24 of 24 publications

· validated civic_curation

A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential.

· Lab Invest · 2004 · PMID 15146165 · validated civic_curation pubmed

Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate.

· Clin Cancer Res · 2006 · PMID 16551858 · validated civic_curation pubmed

Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate.

· Clin Cancer Res · 2006 · PMID 16638875 · validated civic_curation pubmed

KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size.

· Am J Pathol · 2002 · PMID 12000708 · validated civic_curation pubmed

Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors.

· Cancer Res · 1999 · PMID 10485475 · validated civic_curation pubmed

The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study.

· BMC Cancer · 2012 · PMID 22439647 · validated civic_curation pubmed

Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.

· J Clin Oncol · 2008 · PMID 18955458 · validated civic_curation pubmed

Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy.

· Ann Oncol · 2016 · PMID 27371698 · validated civic_curation pubmed

Efficacy and safety of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of imatinib and sunitinib: a multicenter phase II trial.

· J Clin Oncol · 2012 · PMID 22614970 · validated civic_curation pubmed

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial.

· Lancet · 2013 · PMID 23177515 · validated civic_curation pubmed

Ten Years of Treatment with 400 mg Imatinib per Day in a Case of Advanced Gastrointestinal Stromal Tumor.

· Case Rep Oncol · 2011 · PMID 22114577 · validated civic_curation pubmed

Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.

· Clin Cancer Res · 2014 · PMID 25239608 · validated civic_curation pubmed

Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors.

· Clin Cancer Res · 2012 · PMID 22745105 · validated civic_curation pubmed

Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

· Gastroenterology · 2003 · PMID 12949711 · validated civic_curation pubmed

A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal.

· Clin Cancer Res · 2013 · PMID 23231951 · validated civic_curation pubmed

Diana et al. NPJ Precis Oncol 2023

· 2023 · PMID 36593350 · validated cbioportal_study pubmed

Dermawan et al. Clin Cancer Res 2023

· 2023 · PMID 37477937 · validated cbioportal_study pubmed