Publication
Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerGastrointestinal Stromal Tumorcivic_curation1.00
- drugSunitinibcivic_curation1.00
- geneKITcivic_curation1.00
- variantKIT V654Acivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16638875
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT K642E1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | D | Supports Sensitivity Response | — | submitted | EID4145In an in vitro study, GIST882 cells expressing KIT K642E mutation (endogenous expression) demonstrated sensitivity to sunitinib treatment (IC50<50nM). Sensitivity was determined by assessing KIT auto-… (full text at CIViC) PMID 16638875 · Prenen et al., 2006 · Open in CIViC | civic |
| KIT V654A1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID304In GIST tumor cells and patients harboring KIT V654A mutation, SU11248 is effective for those that are refractory to imatinib. PMID 16638875 · Prenen et al., 2006 · Open in CIViC | civic |
| KIT W557_K558del1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | D | Supports Resistance | — | submitted | EID4083In an in vitro study, patient derived tumor cells expressing KIT W557_K558delWK in-frame deletion mutation (endogenous expression) demonstrated sensitivity to sunitinib treatment. Sensitivity was dete… (full text at CIViC) PMID 16638875 · Prenen et al., 2006 · Open in CIViC | civic |
| PDGFRA D842V1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | D | Supports Resistance | — | submitted | EID4059In an in vitro study, Ba/F3 cells expressing PDGFRA D842V mutation (overexpression) demonstrated resistance to sunitinib treatment. Sensitivity was determined by assessing PDGFRA auto-phosphorylation … (full text at CIViC) PMID 16638875 · Prenen et al., 2006 · Open in CIViC | civic |