Publication
The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerGastrointestinal Stromal Tumorcivic_curation1.00
- drugSunitinibcivic_curation1.00
- geneKITcivic_curation1.00
- variantKIT Exon 9 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22439647
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT Exon 9 Mutation1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID1223Primary tumor genotyping of 89 patients with metastatic GIST given 2nd-line sunitinib treatment after prior imatinib therapy failure, revealed an improved response to sunitinib in patients with KIT ex… (full text at CIViC) PMID 22439647 · Rutkowski et al., 2012 · Open in CIViC | civic |
| KIT P551_E554delPMYE1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Resistance | — | submitted | EID4454In a prospective study of 137 gastrointestinal stromal tumor patients who failed imatinib treatment, tumors with KIT exon 11 mutations (52/89) treated with sunitinib were associated with shorter prog… (full text at CIViC) PMID 22439647 · Rutkowski et al., 2012 · Open in CIViC | civic |
| KIT S501_A502INSAY1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Sensitivity Response | — | submitted | EID4501In a prospective study of 137 gastrointestinal stromal tumor patients who failed imatinib treatment, patients with KIT exon 9 mutations (15/89) treated with sunitinib were associated with improved pr… (full text at CIViC) PMID 22439647 · Rutkowski et al., 2012 · Open in CIViC | civic |
| PDGFRA D842V1 | ||||||||
| Sunitinib | Gastrointestinal Stromal Tumor | Predictive | B | Supports Resistance | 3 | submitted | EID4058In a prospective study of 137 gastrointestinal stromal tumor patients who failed imatinib treatment, patients with PDGFRA mutation (12/89; 11/12 tumors genotyped as D842V) treated with sunitinib were… (full text at CIViC) PMID 22439647 · Rutkowski et al., 2012 · Open in CIViC | civic |