Publication
Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors.
Authors not recorded
Cancer Res1999PMID 10485475stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerGastrointestinal Stromal Tumorcivic_curation1.00
- geneKITcivic_curation1.00
- variantKIT Exon 11 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 10485475
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KIT Exon 11 Mutation2 | ||||||||
| (diagnostic) | Gastrointestinal Stromal Tumor | Diagnostic | B | Supports Positive | 2 | accepted | EID225KIT mutation is associated with larger, more invasive tumors, greater pathologic histology and older patients compared to tumors with wildtype KIT. PMID 10485475 · Taniguchi et al., 1999 · Open in CIViC | civic |
| (prognostic) | Gastrointestinal Stromal Tumor | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID376KIT mutation is associated with worse overall and cause-specific prognosis in patients with GIST compared to patients with wildtype KIT. PMID 10485475 · Taniguchi et al., 1999 · Open in CIViC | civic |