Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

6 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Chronic Lymphocytic Leukemia (Broad, Cell 2013) lcll_broad_2013Broad

160 cases with simple somatic mutation data · 160 cases total · 2026-01-07 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Chronic Lymphocytic Leukemia (Broad, Nature 2015) cll_broad_2015Broad

537 cases with simple somatic mutation data · 537 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	113	537	21%	cbioportal
2	ATM	Ssm	82	537	15.3%	cbioportal
3	TP53	Ssm	39	537	7.3%	cbioportal
4	NOTCH1	Ssm	38	537	7.1%	cbioportal
5	POT1	Ssm	35	537	6.5%	cbioportal
6	PCLO	Ssm	28	537	5.2%	cbioportal
7	CHD2	Ssm	26	537	4.8%	cbioportal
8	XPO1	Ssm	24	537	4.5%	cbioportal
9	RPS15	Ssm	22	537	4.1%	cbioportal
11	TTN	Ssm	21	537	3.9%	cbioportal
10	MUC16	Ssm	21	537	3.9%	cbioportal
12	BRAF	Ssm	20	537	3.7%	cbioportal
14	CSMD3	Ssm	19	537	3.5%	cbioportal
13	BIRC3	Ssm	19	537	3.5%	cbioportal
15	EGR2	Ssm	17	537	3.2%	cbioportal
16	MGA	Ssm	17	537	3.2%	cbioportal
18	MYD88	Ssm	16	537	3%	cbioportal
17	LRP1B	Ssm	16	537	3%	cbioportal
19	FAT4	Ssm	15	537	2.8%	cbioportal
20	USH2A	Ssm	15	537	2.8%	cbioportal
21	FAT3	Ssm	14	537	2.6%	cbioportal
22	KRAS	Ssm	14	537	2.6%	cbioportal
23	DDX3X	Ssm	13	537	2.4%	cbioportal
24	PCDH15	Ssm	13	537	2.4%	cbioportal
26	CSMD1	Ssm	12	537	2.2%	cbioportal
28	IGLL5	Ssm	12	537	2.2%	cbioportal
27	FBXW7	Ssm	12	537	2.2%	cbioportal
25	BCOR	Ssm	12	537	2.2%	cbioportal
33	ZFHX4	Ssm	11	537	2%	cbioportal
32	SAMHD1	Ssm	11	537	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (Broad, Nature Genetics 2022) cll_broad_2022Broad

1,075 cases with simple somatic mutation data · 1,154 cases total · 2026-02-19 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	174	1,075	16.2%	cbioportal
2	ATM	Ssm	111	1,075	10.3%	cbioportal
3	TP53	Ssm	91	1,075	8.5%	cbioportal
4	TTN	Ssm	76	1,075	7.1%	cbioportal
5	POT1	Ssm	60	1,075	5.6%	cbioportal
6	PCLO	Ssm	58	1,075	5.4%	cbioportal
7	CHD2	Ssm	55	1,075	5.1%	cbioportal
8	NOTCH1	Ssm	54	1,075	5%	cbioportal
9	XPO1	Ssm	51	1,075	4.7%	cbioportal
10	MUC16	Ssm	49	1,075	4.6%	cbioportal
11	LRP1B	Ssm	48	1,075	4.5%	cbioportal
12	CSMD3	Ssm	42	1,075	3.9%	cbioportal
13	USH2A	Ssm	37	1,075	3.4%	cbioportal
14	FAT4	Ssm	35	1,075	3.3%	cbioportal
15	BRAF	Ssm	34	1,075	3.2%	cbioportal
17	RYR2	Ssm	34	1,075	3.2%	cbioportal
16	MGA	Ssm	34	1,075	3.2%	cbioportal
18	EGR2	Ssm	33	1,075	3.1%	cbioportal
21	ZFHX4	Ssm	33	1,075	3.1%	cbioportal
20	MYD88	Ssm	33	1,075	3.1%	cbioportal
19	FAT1	Ssm	33	1,075	3.1%	cbioportal
22	HMCN1	Ssm	32	1,075	3%	cbioportal
23	BIRC3	Ssm	30	1,075	2.8%	cbioportal
24	ZNF292	Ssm	30	1,075	2.8%	cbioportal
25	DST	Ssm	28	1,075	2.6%	cbioportal
26	CSMD1	Ssm	27	1,075	2.5%	cbioportal
27	DDX3X	Ssm	27	1,075	2.5%	cbioportal
28	FBXW7	Ssm	27	1,075	2.5%	cbioportal
29	KRAS	Ssm	27	1,075	2.5%	cbioportal
30	WDFY3	Ssm	27	1,075	2.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Chronic lymphocytic leukemia (ICGC, Nature Genetics 2011) cllsll_icgc_2011ICGC

105 cases with simple somatic mutation data · 105 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	10	105	9.5%	cbioportal
2	LRP1B	Ssm	5	105	4.8%	cbioportal
3	ATM	Ssm	4	105	3.8%	cbioportal
4	CHD2	Ssm	4	105	3.8%	cbioportal
5	CSMD3	Ssm	4	105	3.8%	cbioportal
6	MUC2	Ssm	4	105	3.8%	cbioportal
7	SI	Ssm	4	105	3.8%	cbioportal
14	SLC4A10	Ssm	3	105	2.9%	cbioportal
13	RIMS2	Ssm	3	105	2.9%	cbioportal
12	POT1	Ssm	3	105	2.9%	cbioportal
11	NXF1	Ssm	3	105	2.9%	cbioportal
10	CDH23	Ssm	3	105	2.9%	cbioportal
9	ASXL1	Ssm	3	105	2.9%	cbioportal
8	ADGRL3	Ssm	3	105	2.9%	cbioportal
60	PTPRB	Ssm	2	105	1.9%	cbioportal
47	MYD88	Ssm	2	105	1.9%	cbioportal
48	NALCN	Ssm	2	105	1.9%	cbioportal
49	NF1	Ssm	2	105	1.9%	cbioportal
50	NLN	Ssm	2	105	1.9%	cbioportal
51	OR2M4	Ssm	2	105	1.9%	cbioportal
52	PCDH11X	Ssm	2	105	1.9%	cbioportal
53	PCSK5	Ssm	2	105	1.9%	cbioportal
54	PHC2	Ssm	2	105	1.9%	cbioportal
55	PNPLA7	Ssm	2	105	1.9%	cbioportal
56	POF1B	Ssm	2	105	1.9%	cbioportal
57	PRDM9	Ssm	2	105	1.9%	cbioportal
58	PRLR	Ssm	2	105	1.9%	cbioportal
59	PROM1	Ssm	2	105	1.9%	cbioportal
61	RELN	Ssm	2	105	1.9%	cbioportal
62	RFTN1	Ssm	2	105	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (IUOPA, Nature 2015) cll_iuopa_2015IUOPA

506 cases with simple somatic mutation data · 506 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	48	506	9.5%	cbioportal
2	SF3B1	Ssm	41	506	8.1%	cbioportal
3	ATM	Ssm	31	506	6.1%	cbioportal
4	IGLL5	Ssm	26	506	5.1%	cbioportal
5	CHD2	Ssm	24	506	4.7%	cbioportal
6	LRP1B	Ssm	23	506	4.5%	cbioportal
7	MUC16	Ssm	20	506	4%	cbioportal
8	MYD88	Ssm	18	506	3.6%	cbioportal
9	POT1	Ssm	17	506	3.4%	cbioportal
11	TP53	Ssm	15	506	3%	cbioportal
10	PCLO	Ssm	15	506	3%	cbioportal
12	KLHL6	Ssm	14	506	2.8%	cbioportal
13	CSMD3	Ssm	13	506	2.6%	cbioportal
14	ZNF292	Ssm	13	506	2.6%	cbioportal
17	MGA	Ssm	12	506	2.4%	cbioportal
15	CSMD1	Ssm	12	506	2.4%	cbioportal
16	DDX3X	Ssm	12	506	2.4%	cbioportal
18	ADGRL3	Ssm	11	506	2.2%	cbioportal
21	TTN	Ssm	10	506	2%	cbioportal
19	BRAF	Ssm	10	506	2%	cbioportal
20	FAT4	Ssm	10	506	2%	cbioportal
22	USH2A	Ssm	10	506	2%	cbioportal
23	BIRC3	Ssm	9	506	1.8%	cbioportal
30	XPO1	Ssm	9	506	1.8%	cbioportal
29	TENM1	Ssm	9	506	1.8%	cbioportal
28	SYNE1	Ssm	9	506	1.8%	cbioportal
27	RYR2	Ssm	9	506	1.8%	cbioportal
26	EGR2	Ssm	9	506	1.8%	cbioportal
25	DTX1	Ssm	9	506	1.8%	cbioportal
24	DNAH9	Ssm	9	506	1.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (MSK, 2026) cllsll_msk_2026MSK

21 cases with simple somatic mutation data · 21 cases total · 2026-03-25 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	14	21	66.7%	cbioportal
2	TP53	Ssm	13	21	61.9%	cbioportal
3	BTK	Ssm	12	21	57.1%	cbioportal
7	MYO18A	Ssm	6	19	31.6%	cbioportal
5	CBFB	Ssm	6	21	28.6%	cbioportal
6	FAT1	Ssm	6	21	28.6%	cbioportal
8	RB1	Ssm	6	21	28.6%	cbioportal
9	SETD2	Ssm	6	21	28.6%	cbioportal
4	ATM	Ssm	6	21	28.6%	cbioportal
12	LRP1B	Ssm	5	19	26.3%	cbioportal
11	FANCL	Ssm	5	19	26.3%	cbioportal
10	ATXN2	Ssm	5	21	23.8%	cbioportal
13	TRAF3	Ssm	4	21	19%	cbioportal
26	ZNF292	Ssm	2	19	10.5%	cbioportal
14	ARID1A	Ssm	2	21	9.5%	cbioportal
22	KRAS	Ssm	2	21	9.5%	cbioportal
21	GRIN2A	Ssm	2	21	9.5%	cbioportal
20	DIS3	Ssm	2	21	9.5%	cbioportal
19	DDX3X	Ssm	2	21	9.5%	cbioportal
18	CXCR4	Ssm	2	21	9.5%	cbioportal
17	BCOR	Ssm	2	21	9.5%	cbioportal
15	ARID1B	Ssm	2	21	9.5%	cbioportal
16	BCL2	Ssm	2	21	9.5%	cbioportal
23	MGA	Ssm	2	21	9.5%	cbioportal
24	MYD88	Ssm	2	21	9.5%	cbioportal
25	TERT	Ssm	2	21	9.5%	cbioportal
35	PPM1D	Ssm	1	19	5.3%	cbioportal
33	PIK3CD	Ssm	1	19	5.3%	cbioportal
36	RICTOR	Ssm	1	21	4.8%	cbioportal
27	ARHGEF28	Ssm	1	21	4.8%	cbioportal

Data updated 22 days agoSource updated 2026-03-25