Hematologic Malignancy
B Lymphoblastic Leukemia/Lymphoma
CI-CAN-00000469Explore in graph →
Hematologic163 active trials1 approved drugs180 evidence items
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Hematologic Malignancy
CI-CAN-00000469Explore in graph →
Genomics
4 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
93 cases with simple somatic mutation data · 93 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KRAS | Ssm | 12 | 93 | 12.9% | cbioportal |
| 2 | NRAS | Ssm | 8 | 93 | 8.6% | cbioportal |
| 3 | FLT3 | Ssm | 5 | 93 | 5.4% | cbioportal |
| 5 | PIK3CA | Ssm | 4 | 93 | 4.3% | cbioportal |
| 4 | PAX5 | Ssm | 4 | 93 | 4.3% | cbioportal |
| 7 | PIK3R1 | Ssm | 3 | 93 | 3.2% | cbioportal |
| 6 | NEB | Ssm | 3 | 93 | 3.2% | cbioportal |
| 12 | SLCO3A1 |
Data updated 22 days agoSource updated 2026-01-05
73 cases with simple somatic mutation data · 73 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NRAS |
739 cases with simple somatic mutation data · 989 cases total · 2026-01-14 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NOTCH1 | Ssm |
150 cases with simple somatic mutation data · 1,978 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NRAS | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 2 |
| 93 |
| 2.2% |
| cbioportal |
| 11 | PDGFRB | Ssm | 2 | 93 | 2.2% | cbioportal |
| 14 | TTLL4 | Ssm | 2 | 93 | 2.2% | cbioportal |
| 9 | DNHD1 | Ssm | 2 | 93 | 2.2% | cbioportal |
| 8 | CHD7 | Ssm | 2 | 93 | 2.2% | cbioportal |
| 10 | FGF5 | Ssm | 2 | 93 | 2.2% | cbioportal |
| 13 | TP53 | Ssm | 2 | 93 | 2.2% | cbioportal |
| 21 | EZH2 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 20 | ERCC3 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 19 | ERCC2 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 18 | DDX10 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 17 | CREBBP | Ssm | 1 | 93 | 1.1% | cbioportal |
| 16 | BMAL2 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 15 | AXL | Ssm | 1 | 93 | 1.1% | cbioportal |
| 30 | PLXNA2 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 29 | PDE4B | Ssm | 1 | 93 | 1.1% | cbioportal |
| 28 | PCDHGA5 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 27 | PCDH19 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 26 | NSD2 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 25 | NF1 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 24 | MED12 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 23 | JAG1 | Ssm | 1 | 93 | 1.1% | cbioportal |
| 22 | IGSF9 | Ssm | 1 | 93 | 1.1% | cbioportal |
| Ssm |
| 18 |
| 73 |
| 24.7% |
| cbioportal |
| 2 | KMT2D | Ssm | 14 | 73 | 19.2% | cbioportal |
| 3 | SETD2 | Ssm | 10 | 73 | 13.7% | cbioportal |
| 4 | TBL1XR1 | Ssm | 8 | 73 | 11% | cbioportal |
| 5 | ZFP36L2 | Ssm | 6 | 73 | 8.2% | cbioportal |
| 8 | ZEB2 | Ssm | 5 | 73 | 6.8% | cbioportal |
| 7 | NCOR1 | Ssm | 5 | 73 | 6.8% | cbioportal |
| 6 | KRAS | Ssm | 5 | 73 | 6.8% | cbioportal |
| 9 | PAX5 | Ssm | 4 | 73 | 5.5% | cbioportal |
| 11 | TP53 | Ssm | 4 | 73 | 5.5% | cbioportal |
| 10 | PTPN11 | Ssm | 4 | 73 | 5.5% | cbioportal |
| 16 | MYC | Ssm | 3 | 73 | 4.1% | cbioportal |
| 17 | MYCBP2 | Ssm | 3 | 73 | 4.1% | cbioportal |
| 18 | PIK3R1 | Ssm | 3 | 73 | 4.1% | cbioportal |
| 19 | TTN | Ssm | 3 | 73 | 4.1% | cbioportal |
| 15 | MED12 | Ssm | 3 | 73 | 4.1% | cbioportal |
| 12 | CTCF | Ssm | 3 | 73 | 4.1% | cbioportal |
| 13 | ERG | Ssm | 3 | 73 | 4.1% | cbioportal |
| 14 | KDM6A | Ssm | 3 | 73 | 4.1% | cbioportal |
| 30 | FNDC1 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 20 | ABCC8 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 25 | DNAH9 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 24 | DACT2 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 23 | CCN3 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 22 | BRWD1 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 21 | ADGRV1 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 26 | EGFR | Ssm | 2 | 73 | 2.7% | cbioportal |
| 27 | EHMT2 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 28 | ETV6 | Ssm | 2 | 73 | 2.7% | cbioportal |
| 29 | FLT3 | Ssm | 2 | 73 | 2.7% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05
| 159 |
| 739 |
| 21.5% |
| cbioportal |
| 2 | KRAS | Ssm | 90 | 739 | 12.2% | cbioportal |
| 3 | NRAS | Ssm | 88 | 739 | 11.9% | cbioportal |
| 4 | FBXW7 | Ssm | 59 | 739 | 8% | cbioportal |
| 5 | PHF6 | Ssm | 44 | 739 | 6% | cbioportal |
| 6 | TTN | Ssm | 35 | 739 | 4.7% | cbioportal |
| 7 | PAX5 | Ssm | 33 | 739 | 4.5% | cbioportal |
| 8 | KMT2D | Ssm | 32 | 739 | 4.3% | cbioportal |
| 9 | PTEN | Ssm | 29 | 739 | 3.9% | cbioportal |
| 10 | FLT3 | Ssm | 28 | 739 | 3.8% | cbioportal |
| 11 | USP7 | Ssm | 28 | 739 | 3.8% | cbioportal |
| 12 | DNM2 | Ssm | 26 | 739 | 3.5% | cbioportal |
| 13 | CREBBP | Ssm | 25 | 739 | 3.4% | cbioportal |
| 14 | BCL11B | Ssm | 24 | 739 | 3.2% | cbioportal |
| 15 | NSD2 | Ssm | 23 | 739 | 3.1% | cbioportal |
| 16 | PTPN11 | Ssm | 23 | 739 | 3.1% | cbioportal |
| 17 | JAK2 | Ssm | 22 | 739 | 3% | cbioportal |
| 19 | SETD2 | Ssm | 19 | 739 | 2.6% | cbioportal |
| 18 | ETV6 | Ssm | 19 | 739 | 2.6% | cbioportal |
| 23 | TP53 | Ssm | 17 | 739 | 2.3% | cbioportal |
| 22 | IKZF1 | Ssm | 17 | 739 | 2.3% | cbioportal |
| 21 | FSIP2 | Ssm | 17 | 739 | 2.3% | cbioportal |
| 20 | CTCF | Ssm | 17 | 739 | 2.3% | cbioportal |
| 25 | USH2A | Ssm | 16 | 739 | 2.2% | cbioportal |
| 24 | JAK3 | Ssm | 16 | 739 | 2.2% | cbioportal |
| 28 | ZFHX4 | Ssm | 15 | 739 | 2% | cbioportal |
| 27 | JAK1 | Ssm | 15 | 739 | 2% | cbioportal |
| 26 | IL7R | Ssm | 15 | 739 | 2% | cbioportal |
| 29 | EZH2 | Ssm | 14 | 739 | 1.9% | cbioportal |
| 30 | MUC16 | Ssm | 14 | 739 | 1.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-14
| 16 |
| 150 |
| 10.7% |
| cbioportal |
| 2 | KRAS | Ssm | 8 | 150 | 5.3% | cbioportal |
| 4 | PTPN11 | Ssm | 6 | 150 | 4% | cbioportal |
| 3 | CREBBP | Ssm | 6 | 150 | 4% | cbioportal |
| 5 | TP53 | Ssm | 6 | 150 | 4% | cbioportal |
| 7 | JAK2 | Ssm | 5 | 150 | 3.3% | cbioportal |
| 8 | NSD2 | Ssm | 5 | 150 | 3.3% | cbioportal |
| 6 | FLT3 | Ssm | 5 | 150 | 3.3% | cbioportal |
| 9 | CDK11A | Ssm | 4 | 150 | 2.7% | cbioportal |
| 10 | NOTCH2 | Ssm | 4 | 150 | 2.7% | cbioportal |
| 11 | DOT1L | Ssm | 3 | 150 | 2% | cbioportal |
| 12 | HLA-C | Ssm | 3 | 150 | 2% | cbioportal |
| 13 | KMT2D | Ssm | 3 | 150 | 2% | cbioportal |
| 15 | QRICH2 | Ssm | 3 | 150 | 2% | cbioportal |
| 14 | OVGP1 | Ssm | 3 | 150 | 2% | cbioportal |
| 16 | TAS2R19 | Ssm | 3 | 150 | 2% | cbioportal |
| 23 | EZH2 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 24 | FCGBP | Ssm | 2 | 150 | 1.3% | cbioportal |
| 25 | FHL3 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 26 | FURIN | Ssm | 2 | 150 | 1.3% | cbioportal |
| 27 | GCNA | Ssm | 2 | 150 | 1.3% | cbioportal |
| 29 | HDHD5 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 28 | GNB1 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 30 | HLA-DRB1 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 17 | APOE | Ssm | 2 | 150 | 1.3% | cbioportal |
| 18 | ATF7IP | Ssm | 2 | 150 | 1.3% | cbioportal |
| 19 | CCDC186 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 20 | CEP162 | Ssm | 2 | 150 | 1.3% | cbioportal |
| 21 | ECPAS | Ssm | 2 | 150 | 1.3% | cbioportal |
| 22 | ELL | Ssm | 2 | 150 | 1.3% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05