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CancerIndex

Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Top 15 by Trial Gap IndexMalignant Colon Neoplasm+52Cutaneous Melanoma+28Malignant Laryngeal Neoplasm+24Malignant Bladder Neoplasm+20Malignant Esophageal Neoplasm+16Malignant Pancreatic Neoplasm+12Malignant Prostate Neoplasm+12Malignant Salivary Gland Neop…+12Malignant Kidney Neoplasm+8Malignant Mesothelioma+8Malignant Testicular Neoplasm+8Malignant Liver Neoplasm+4Malignant Lung Neoplasm0Malignant Penile Neoplasm0Malignant Thyroid Gland Neopl…0
RankΔCancerTrial Gap Index (percentile points)PercentileConfidenceSourcesWhy #n?
1=Malignant Colon Neoplasm+52100Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
21494
formula
percentile(mortality_count) − percentile(active_trials)
activity
225
burdenPercentile
92
activityPercentile
40

ranking row 2598426

2=Cutaneous Melanoma+2896Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
6002
formula
percentile(mortality_count) − percentile(active_trials)
activity
78
burdenPercentile
52
activityPercentile
24

ranking row 2598427

3=Malignant Laryngeal Neoplasm+2492Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
2951
formula
percentile(mortality_count) − percentile(active_trials)
activity
66
burdenPercentile
40
activityPercentile
16

ranking row 2598428

4=Malignant Bladder Neoplasm+2088Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
10428
formula
percentile(mortality_count) − percentile(active_trials)
activity
346
burdenPercentile
68
activityPercentile
48

ranking row 2598429

5=Malignant Esophageal Neoplasm+1684Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
11416
formula
percentile(mortality_count) − percentile(active_trials)
activity
518
burdenPercentile
76
activityPercentile
60

ranking row 2598430

6=Malignant Pancreatic Neoplasm+1280Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
18699
formula
percentile(mortality_count) − percentile(active_trials)
activity
904
burdenPercentile
88
activityPercentile
76

ranking row 2598431

6=Malignant Prostate Neoplasm+1280Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
28560
formula
percentile(mortality_count) − percentile(active_trials)
activity
1375
burdenPercentile
96
activityPercentile
84

ranking row 2598433

6=Malignant Salivary Gland Neoplasm+1280Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
541
formula
percentile(mortality_count) − percentile(active_trials)
activity
63
burdenPercentile
24
activityPercentile
12

ranking row 2598432

9=Malignant Kidney Neoplasm+868Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
8436
formula
percentile(mortality_count) − percentile(active_trials)
activity
453
burdenPercentile
64
activityPercentile
56

ranking row 2598435

9=Malignant Mesothelioma+868Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
2044
formula
percentile(mortality_count) − percentile(active_trials)
activity
96
burdenPercentile
36
activityPercentile
28

ranking row 2598434

9=Malignant Testicular Neoplasm+868Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
399
formula
percentile(mortality_count) − percentile(active_trials)
activity
43
burdenPercentile
12
activityPercentile
4

ranking row 2598436

12=Malignant Liver Neoplasm+456Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
13657
formula
percentile(mortality_count) − percentile(active_trials)
activity
906
burdenPercentile
84
activityPercentile
80

ranking row 2598437

13=Malignant Lung Neoplasm052Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
87698
formula
percentile(mortality_count) − percentile(active_trials)
activity
2644
burdenPercentile
100
activityPercentile
100

ranking row 2598438

13=Malignant Penile Neoplasm052Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
258
formula
percentile(mortality_count) − percentile(active_trials)
activity
43
burdenPercentile
4
activityPercentile
4

ranking row 2598440

13=Malignant Thyroid Gland Neoplasm052Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
723
formula
percentile(mortality_count) − percentile(active_trials)
activity
176
burdenPercentile
32
activityPercentile
32

ranking row 2598439

16=Hodgkin Lymphoma-840Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
714
formula
percentile(mortality_count) − percentile(active_trials)
activity
179
burdenPercentile
28
activityPercentile
36

ranking row 2598442

16=Leukemia-840Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
12912
formula
percentile(mortality_count) − percentile(active_trials)
activity
1769
burdenPercentile
80
activityPercentile
88

ranking row 2598441

16=Malignant Gastric Neoplasm-840Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
6703
formula
percentile(mortality_count) − percentile(active_trials)
activity
652
burdenPercentile
56
activityPercentile
64

ranking row 2598443

16=Malignant Hypopharyngeal Neoplasm-840Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
253
formula
percentile(mortality_count) − percentile(active_trials)
activity
53
burdenPercentile
0
activityPercentile
8

ranking row 2598444

16=Malignant Rectal Neoplasm-840Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5579
formula
percentile(mortality_count) − percentile(active_trials)
activity
386
burdenPercentile
44
activityPercentile
52

ranking row 2598445

21=Malignant Anal Neoplasm-1220Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
335
formula
percentile(mortality_count) − percentile(active_trials)
activity
68
burdenPercentile
8
activityPercentile
20

ranking row 2598447

21=Malignant Central Nervous System Neoplasm-1220Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
7977
formula
percentile(mortality_count) − percentile(active_trials)
activity
823
burdenPercentile
60
activityPercentile
72

ranking row 2598446

23=Multiple Myeloma-2012Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5881
formula
percentile(mortality_count) − percentile(active_trials)
activity
814
burdenPercentile
48
activityPercentile
68

ranking row 2598448

23=Non-Hodgkin Lymphoma-2012Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
11047
formula
percentile(mortality_count) − percentile(active_trials)
activity
2168
burdenPercentile
72
activityPercentile
92

ranking row 2598449

25=Malignant Nasopharyngeal Neoplasm-244Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
479
formula
percentile(mortality_count) − percentile(active_trials)
activity
261
burdenPercentile
20
activityPercentile
44

ranking row 2598450

26=Malignant Breast Neoplasm-800Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
439
formula
percentile(mortality_count) − percentile(active_trials)
activity
2627
burdenPercentile
16
activityPercentile
96

ranking row 2598451

Data updated 16 hours agoSource updated unknown26 eligible entities · inputs hash b2e46c8e77141e4d58afa613