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CancerIndex

Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Top 15 by Trial Gap IndexMalignant Colon Neoplasm+55.6Malignant Vulvar Neoplasm+18.5Cutaneous Melanoma+14.8Malignant Laryngeal Neoplasm+14.8Malignant Vaginal Neoplasm+14.8Malignant Ovarian Neoplasm+14.8Malignant Bladder Neoplasm+11.2Malignant Pancreatic Neoplasm+7.4Malignant Kidney Neoplasm+3.7Malignant Thyroid Gland Neopl…+3.7Malignant Breast Neoplasm0Malignant Gastric Neoplasm0Malignant Lung Neoplasm0Malignant Rectal Neoplasm0Multiple Myeloma-3.7
RankΔCancerTrial Gap Index (percentile points)PercentileConfidenceSourcesWhy #n?
1=Malignant Colon Neoplasm+55.6100Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
24318
formula
percentile(mortality_count) − percentile(active_trials)
activity
225
burdenPercentile
92.6
activityPercentile
37

ranking row 2593558

2=Malignant Vulvar Neoplasm+18.596.3Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
794
formula
percentile(mortality_count) − percentile(active_trials)
activity
54
burdenPercentile
25.9
activityPercentile
7.4

ranking row 2593559

3=Cutaneous Melanoma+14.892.6Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
2788
formula
percentile(mortality_count) − percentile(active_trials)
activity
78
burdenPercentile
37
activityPercentile
22.2

ranking row 2593560

3=Malignant Laryngeal Neoplasm+14.892.6Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
801
formula
percentile(mortality_count) − percentile(active_trials)
activity
66
burdenPercentile
29.6
activityPercentile
14.8

ranking row 2593561

3=Malignant Vaginal Neoplasm+14.892.6Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
378
formula
percentile(mortality_count) − percentile(active_trials)
activity
31
burdenPercentile
14.8
activityPercentile
0

ranking row 2593562

6=Malignant Ovarian Neoplasm+14.881.5Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
14682
formula
percentile(mortality_count) − percentile(active_trials)
activity
684
burdenPercentile
85.2
activityPercentile
70.4

ranking row 2593563

7=Malignant Bladder Neoplasm+11.277.8Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
4124
formula
percentile(mortality_count) − percentile(active_trials)
activity
346
burdenPercentile
55.6
activityPercentile
44.4

ranking row 2593564

8=Malignant Pancreatic Neoplasm+7.474.1Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
15387
formula
percentile(mortality_count) − percentile(active_trials)
activity
904
burdenPercentile
88.9
activityPercentile
81.5

ranking row 2593565

9=Malignant Kidney Neoplasm+3.770.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
4578
formula
percentile(mortality_count) − percentile(active_trials)
activity
453
burdenPercentile
59.3
activityPercentile
55.6

ranking row 2593566

9=Malignant Thyroid Gland Neoplasm+3.770.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
809
formula
percentile(mortality_count) − percentile(active_trials)
activity
176
burdenPercentile
33.3
activityPercentile
29.6

ranking row 2593567

11=Malignant Breast Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
41514
formula
percentile(mortality_count) − percentile(active_trials)
activity
2627
burdenPercentile
96.3
activityPercentile
96.3

ranking row 2593568

11=Malignant Gastric Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5065
formula
percentile(mortality_count) − percentile(active_trials)
activity
652
burdenPercentile
66.7
activityPercentile
66.7

ranking row 2593569

11=Malignant Lung Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
67509
formula
percentile(mortality_count) − percentile(active_trials)
activity
2644
burdenPercentile
100
activityPercentile
100

ranking row 2593570

11=Malignant Rectal Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3814
formula
percentile(mortality_count) − percentile(active_trials)
activity
386
burdenPercentile
48.1
activityPercentile
48.1

ranking row 2593571

15=Multiple Myeloma-3.748.1Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5242
formula
percentile(mortality_count) − percentile(active_trials)
activity
814
burdenPercentile
70.4
activityPercentile
74.1

ranking row 2593572

16=Malignant Salivary Gland Neoplasm-3.744.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
267
formula
percentile(mortality_count) − percentile(active_trials)
activity
63
burdenPercentile
7.4
activityPercentile
11.1

ranking row 2593573

17=Malignant Hypopharyngeal Neoplasm-3.740.7Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
70
formula
percentile(mortality_count) − percentile(active_trials)
activity
53
burdenPercentile
0
activityPercentile
3.7

ranking row 2593574

18=Malignant Central Nervous System Neoplasm-3.737Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5705
formula
percentile(mortality_count) − percentile(active_trials)
activity
823
burdenPercentile
74.1
activityPercentile
77.8

ranking row 2593575

19=Malignant Cervical Neoplasm-7.433.3Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3952
formula
percentile(mortality_count) − percentile(active_trials)
activity
505
burdenPercentile
51.9
activityPercentile
59.3

ranking row 2593577

19=Malignant Mesothelioma-7.433.3Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
426
formula
percentile(mortality_count) − percentile(active_trials)
activity
96
burdenPercentile
18.5
activityPercentile
25.9

ranking row 2593576

21=Malignant Anal Neoplasm-7.425.9Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
326
formula
percentile(mortality_count) − percentile(active_trials)
activity
68
burdenPercentile
11.1
activityPercentile
18.5

ranking row 2593578

22=Malignant Uterine Corpus Neoplasm-7.522.2Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3187
formula
percentile(mortality_count) − percentile(active_trials)
activity
411
burdenPercentile
44.4
activityPercentile
51.9

ranking row 2593579

23=Non-Hodgkin Lymphoma-11.118.5Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
10372
formula
percentile(mortality_count) − percentile(active_trials)
activity
2168
burdenPercentile
81.5
activityPercentile
92.6

ranking row 2593580

24=Hodgkin Lymphoma-11.114.8Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
601
formula
percentile(mortality_count) − percentile(active_trials)
activity
179
burdenPercentile
22.2
activityPercentile
33.3

ranking row 2593581

25=Leukemia-11.111.1Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
9523
formula
percentile(mortality_count) − percentile(active_trials)
activity
1769
burdenPercentile
77.8
activityPercentile
88.9

ranking row 2593582

26=Malignant Liver Neoplasm-22.27.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5036
formula
percentile(mortality_count) − percentile(active_trials)
activity
906
burdenPercentile
63
activityPercentile
85.2

ranking row 2593583

27=Malignant Esophageal Neoplasm-22.33.7Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
2911
formula
percentile(mortality_count) − percentile(active_trials)
activity
518
burdenPercentile
40.7
activityPercentile
63

ranking row 2593584

28=Malignant Nasopharyngeal Neoplasm-370Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
240
formula
percentile(mortality_count) − percentile(active_trials)
activity
261
burdenPercentile
3.7
activityPercentile
40.7

ranking row 2593585

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 10982933649af0e0443db036