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CancerIndex

Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Top 15 by Trial Gap IndexMalignant Colon Neoplasm+55.6Malignant Vulvar Neoplasm+22.2Cutaneous Melanoma+14.8Malignant Vaginal Neoplasm+14.8Malignant Ovarian Neoplasm+14.8Malignant Laryngeal Neoplasm+11.1Malignant Bladder Neoplasm+7.5Malignant Pancreatic Neoplasm+7.4Malignant Kidney Neoplasm+3.7Malignant Thyroid Gland Neopl…+3.7Malignant Breast Neoplasm0Malignant Lung Neoplasm0Malignant Rectal Neoplasm0Malignant Cervical Neoplasm-3.7Malignant Salivary Gland Neop…-3.7
RankΔCancerTrial Gap Index (percentile points)PercentileConfidenceSourcesWhy #n?
1=Malignant Colon Neoplasm+55.6100Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
23998
formula
percentile(mortality_count) − percentile(active_trials)
activity
225
burdenPercentile
92.6
activityPercentile
37

ranking row 2594143

2=Malignant Vulvar Neoplasm+22.296.3Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
775
formula
percentile(mortality_count) − percentile(active_trials)
activity
54
burdenPercentile
29.6
activityPercentile
7.4

ranking row 2594144

3=Cutaneous Melanoma+14.892.6Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
2855
formula
percentile(mortality_count) − percentile(active_trials)
activity
78
burdenPercentile
37
activityPercentile
22.2

ranking row 2594145

3=Malignant Vaginal Neoplasm+14.892.6Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
391
formula
percentile(mortality_count) − percentile(active_trials)
activity
31
burdenPercentile
14.8
activityPercentile
0

ranking row 2594146

5=Malignant Ovarian Neoplasm+14.885.2Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
14657
formula
percentile(mortality_count) − percentile(active_trials)
activity
684
burdenPercentile
85.2
activityPercentile
70.4

ranking row 2594147

6=Malignant Laryngeal Neoplasm+11.181.5Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
771
formula
percentile(mortality_count) − percentile(active_trials)
activity
66
burdenPercentile
25.9
activityPercentile
14.8

ranking row 2594148

7=Malignant Bladder Neoplasm+7.577.8Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3907
formula
percentile(mortality_count) − percentile(active_trials)
activity
346
burdenPercentile
51.9
activityPercentile
44.4

ranking row 2594149

8=Malignant Pancreatic Neoplasm+7.474.1Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
15717
formula
percentile(mortality_count) − percentile(active_trials)
activity
904
burdenPercentile
88.9
activityPercentile
81.5

ranking row 2594150

9=Malignant Kidney Neoplasm+3.770.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
4619
formula
percentile(mortality_count) − percentile(active_trials)
activity
453
burdenPercentile
59.3
activityPercentile
55.6

ranking row 2594151

9=Malignant Thyroid Gland Neoplasm+3.770.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
779
formula
percentile(mortality_count) − percentile(active_trials)
activity
176
burdenPercentile
33.3
activityPercentile
29.6

ranking row 2594152

11=Malignant Breast Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
41619
formula
percentile(mortality_count) − percentile(active_trials)
activity
2627
burdenPercentile
96.3
activityPercentile
96.3

ranking row 2594153

11=Malignant Lung Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
68084
formula
percentile(mortality_count) − percentile(active_trials)
activity
2644
burdenPercentile
100
activityPercentile
100

ranking row 2594154

11=Malignant Rectal Neoplasm063Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3795
formula
percentile(mortality_count) − percentile(active_trials)
activity
386
burdenPercentile
48.1
activityPercentile
48.1

ranking row 2594155

14=Malignant Cervical Neoplasm-3.751.9Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3919
formula
percentile(mortality_count) − percentile(active_trials)
activity
505
burdenPercentile
55.6
activityPercentile
59.3

ranking row 2594156

15=Malignant Salivary Gland Neoplasm-3.748.1Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
259
formula
percentile(mortality_count) − percentile(active_trials)
activity
63
burdenPercentile
7.4
activityPercentile
11.1

ranking row 2594157

16=Malignant Hypopharyngeal Neoplasm-3.744.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
67
formula
percentile(mortality_count) − percentile(active_trials)
activity
53
burdenPercentile
0
activityPercentile
3.7

ranking row 2594158

17=Malignant Central Nervous System Neoplasm-3.740.7Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5779
formula
percentile(mortality_count) − percentile(active_trials)
activity
823
burdenPercentile
74.1
activityPercentile
77.8

ranking row 2594159

17=Malignant Gastric Neoplasm-3.740.7Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5055
formula
percentile(mortality_count) − percentile(active_trials)
activity
652
burdenPercentile
63
activityPercentile
66.7

ranking row 2594160

19=Multiple Myeloma-7.433.3Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5221
formula
percentile(mortality_count) − percentile(active_trials)
activity
814
burdenPercentile
66.7
activityPercentile
74.1

ranking row 2594161

20=Malignant Mesothelioma-7.429.6Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
469
formula
percentile(mortality_count) − percentile(active_trials)
activity
96
burdenPercentile
18.5
activityPercentile
25.9

ranking row 2594162

21=Malignant Anal Neoplasm-7.425.9Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
369
formula
percentile(mortality_count) − percentile(active_trials)
activity
68
burdenPercentile
11.1
activityPercentile
18.5

ranking row 2594163

22=Malignant Uterine Corpus Neoplasm-7.522.2Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
3261
formula
percentile(mortality_count) − percentile(active_trials)
activity
411
burdenPercentile
44.4
activityPercentile
51.9

ranking row 2594164

23=Non-Hodgkin Lymphoma-11.118.5Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
10076
formula
percentile(mortality_count) − percentile(active_trials)
activity
2168
burdenPercentile
81.5
activityPercentile
92.6

ranking row 2594165

24=Hodgkin Lymphoma-11.114.8Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
622
formula
percentile(mortality_count) − percentile(active_trials)
activity
179
burdenPercentile
22.2
activityPercentile
33.3

ranking row 2594166

25=Leukemia-11.111.1Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
9504
formula
percentile(mortality_count) − percentile(active_trials)
activity
1769
burdenPercentile
77.8
activityPercentile
88.9

ranking row 2594167

26=Malignant Liver Neoplasm-14.87.4Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
5224
formula
percentile(mortality_count) − percentile(active_trials)
activity
906
burdenPercentile
70.4
activityPercentile
85.2

ranking row 2594168

27=Malignant Esophageal Neoplasm-22.33.7Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
2939
formula
percentile(mortality_count) − percentile(active_trials)
activity
518
burdenPercentile
40.7
activityPercentile
63

ranking row 2594169

28=Malignant Nasopharyngeal Neoplasm-370Medium confidencecdc-uscsclinicaltrialscdc-wonderseeriarc-globocan
inputs
deaths
193
formula
percentile(mortality_count) − percentile(active_trials)
activity
261
burdenPercentile
3.7
activityPercentile
40.7

ranking row 2594170

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 179b67b452840a2fbefc1f46