Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Trial Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	▲1	Malignant Colon Neoplasm	+51.9	100	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 19458 formula percentile(mortality_count) − percentile(active_trials) activity 225 burdenPercentile 88.9 activityPercentile 37 ranking row 2606253
2	▲1	Malignant Vulvar Neoplasm	+25.9	96.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 1436 formula percentile(mortality_count) − percentile(active_trials) activity 54 burdenPercentile 33.3 activityPercentile 7.4 ranking row 2606254
3	▲3	Malignant Uterine Corpus Neoplasm	+14.8	92.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 7337 formula percentile(mortality_count) − percentile(active_trials) activity 411 burdenPercentile 66.7 activityPercentile 51.9 ranking row 2606255
4	=	Cutaneous Melanoma	+14.8	88.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 2861 formula percentile(mortality_count) − percentile(active_trials) activity 78 burdenPercentile 37 activityPercentile 22.2 ranking row 2606256
4	▲1	Malignant Vaginal Neoplasm	+14.8	88.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 441 formula percentile(mortality_count) − percentile(active_trials) activity 31 burdenPercentile 14.8 activityPercentile 0 ranking row 2606257
6	=	Malignant Ovarian Neoplasm	+14.8	81.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 13430 formula percentile(mortality_count) − percentile(active_trials) activity 684 burdenPercentile 85.2 activityPercentile 70.4 ranking row 2606258
7	▲1	Malignant Rectal Neoplasm	+11.2	77.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4901 formula percentile(mortality_count) − percentile(active_trials) activity 386 burdenPercentile 59.3 activityPercentile 48.1 ranking row 2606259
8	▲1	Malignant Pancreatic Neoplasm	+11.1	74.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 22994 formula percentile(mortality_count) − percentile(active_trials) activity 904 burdenPercentile 92.6 activityPercentile 81.5 ranking row 2606260
9	▲1	Malignant Bladder Neoplasm	+7.5	70.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4644 formula percentile(mortality_count) − percentile(active_trials) activity 346 burdenPercentile 51.9 activityPercentile 44.4 ranking row 2606261
10	▲2	Malignant Anal Neoplasm	+7.4	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 970 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 25.9 activityPercentile 18.5 ranking row 2606263
10	▲3	Malignant Laryngeal Neoplasm	+7.4	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 761 formula percentile(mortality_count) − percentile(active_trials) activity 66 burdenPercentile 22.2 activityPercentile 14.8 ranking row 2606262
12	▲5	Malignant Breast Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 42310 formula percentile(mortality_count) − percentile(active_trials) activity 2627 burdenPercentile 96.3 activityPercentile 96.3 ranking row 2606264
12	▲4	Malignant Kidney Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4793 formula percentile(mortality_count) − percentile(active_trials) activity 453 burdenPercentile 55.6 activityPercentile 55.6 ranking row 2606266
12	▲5	Malignant Lung Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 62954 formula percentile(mortality_count) − percentile(active_trials) activity 2644 burdenPercentile 100 activityPercentile 100 ranking row 2606265
12	▲16	Malignant Thyroid Gland Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 1154 formula percentile(mortality_count) − percentile(active_trials) activity 176 burdenPercentile 29.6 activityPercentile 29.6 ranking row 2606267
16	▲5	Malignant Salivary Gland Neoplasm	-3.7	44.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 373 formula percentile(mortality_count) − percentile(active_trials) activity 63 burdenPercentile 7.4 activityPercentile 11.1 ranking row 2606268
17	▲5	Malignant Hypopharyngeal Neoplasm	-3.7	40.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 105 formula percentile(mortality_count) − percentile(active_trials) activity 53 burdenPercentile 0 activityPercentile 3.7 ranking row 2606269
18	▼1	Malignant Liver Neoplasm	-3.7	37	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 9891 formula percentile(mortality_count) − percentile(active_trials) activity 906 burdenPercentile 81.5 activityPercentile 85.2 ranking row 2606270
19	▲4	Malignant Central Nervous System Neoplasm	-7.4	33.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 7759 formula percentile(mortality_count) − percentile(active_trials) activity 823 burdenPercentile 70.4 activityPercentile 77.8 ranking row 2606271
20	=	Malignant Mesothelioma	-7.4	29.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 626 formula percentile(mortality_count) − percentile(active_trials) activity 96 burdenPercentile 18.5 activityPercentile 25.9 ranking row 2606272
21	▲3	Multiple Myeloma	-11.1	25.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 5431 formula percentile(mortality_count) − percentile(active_trials) activity 814 burdenPercentile 63 activityPercentile 74.1 ranking row 2606273
22	▲7	Leukemia	-11.1	22.2	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 9810 formula percentile(mortality_count) − percentile(active_trials) activity 1769 burdenPercentile 77.8 activityPercentile 88.9 ranking row 2606274
23	▲4	Malignant Cervical Neoplasm	-11.2	18.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4366 formula percentile(mortality_count) − percentile(active_trials) activity 505 burdenPercentile 48.1 activityPercentile 59.3 ranking row 2606275
24	▲7	Non-Hodgkin Lymphoma	-18.5	14.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 8501 formula percentile(mortality_count) − percentile(active_trials) activity 2168 burdenPercentile 74.1 activityPercentile 92.6 ranking row 2606276
25	▲9	Hodgkin Lymphoma	-22.2	11.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 407 formula percentile(mortality_count) − percentile(active_trials) activity 179 burdenPercentile 11.1 activityPercentile 33.3 ranking row 2606277
26	▲5	Malignant Esophageal Neoplasm	-22.3	7.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3185 formula percentile(mortality_count) − percentile(active_trials) activity 518 burdenPercentile 40.7 activityPercentile 63 ranking row 2606278
27	▲6	Malignant Gastric Neoplasm	-22.3	3.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4302 formula percentile(mortality_count) − percentile(active_trials) activity 652 burdenPercentile 44.4 activityPercentile 66.7 ranking row 2606279
28	▲7	Malignant Nasopharyngeal Neoplasm	-37	0	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 199 formula percentile(mortality_count) − percentile(active_trials) activity 261 burdenPercentile 3.7 activityPercentile 40.7 ranking row 2606280

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash e65d7b7242674f7aa5d3a9a0

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(active_trials)
Version: ci-trial-gap-v1
Scope: USA · Female · all ages · 2021 · top-level cancers
Scope key: geo=USA|sex=female|age=all|year=2021|level=top
Eligible entities: 28
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: e65d7b7242674f7aa5d3a9a0
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality clinicaltrials cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
active_trials
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.