Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Trial Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Colon Neoplasm	+55.6	100	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 20384 formula percentile(mortality_count) − percentile(active_trials) activity 225 burdenPercentile 92.6 activityPercentile 37 ranking row 2600578
2	=	Malignant Vulvar Neoplasm	+25.9	96.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 1085 formula percentile(mortality_count) − percentile(active_trials) activity 54 burdenPercentile 33.3 activityPercentile 7.4 ranking row 2600579
3	=	Cutaneous Melanoma	+18.5	92.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3163 formula percentile(mortality_count) − percentile(active_trials) activity 78 burdenPercentile 40.7 activityPercentile 22.2 ranking row 2600580
4	=	Malignant Ovarian Neoplasm	+14.8	88.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 14195 formula percentile(mortality_count) − percentile(active_trials) activity 684 burdenPercentile 85.2 activityPercentile 70.4 ranking row 2600581
5	=	Malignant Bladder Neoplasm	+11.2	85.2	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4484 formula percentile(mortality_count) − percentile(active_trials) activity 346 burdenPercentile 55.6 activityPercentile 44.4 ranking row 2600582
6	=	Malignant Vaginal Neoplasm	+11.1	81.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 430 formula percentile(mortality_count) − percentile(active_trials) activity 31 burdenPercentile 11.1 activityPercentile 0 ranking row 2600583
7	=	Malignant Laryngeal Neoplasm	+11.1	77.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 711 formula percentile(mortality_count) − percentile(active_trials) activity 66 burdenPercentile 25.9 activityPercentile 14.8 ranking row 2600584
8	=	Malignant Pancreatic Neoplasm	+7.4	74.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 19664 formula percentile(mortality_count) − percentile(active_trials) activity 904 burdenPercentile 88.9 activityPercentile 81.5 ranking row 2600585
9	=	Malignant Kidney Neoplasm	+7.4	70.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4714 formula percentile(mortality_count) − percentile(active_trials) activity 453 burdenPercentile 63 activityPercentile 55.6 ranking row 2600586
10	=	Malignant Anal Neoplasm	+3.7	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 570 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 22.2 activityPercentile 18.5 ranking row 2600587
11	=	Malignant Breast Neoplasm	0	63	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 41211 formula percentile(mortality_count) − percentile(active_trials) activity 2627 burdenPercentile 96.3 activityPercentile 96.3 ranking row 2600588
11	=	Malignant Lung Neoplasm	0	63	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 70667 formula percentile(mortality_count) − percentile(active_trials) activity 2644 burdenPercentile 100 activityPercentile 100 ranking row 2600589
11	=	Malignant Rectal Neoplasm	0	63	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4133 formula percentile(mortality_count) − percentile(active_trials) activity 386 burdenPercentile 48.1 activityPercentile 48.1 ranking row 2600591
11	=	Malignant Thyroid Gland Neoplasm	0	63	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 1036 formula percentile(mortality_count) − percentile(active_trials) activity 176 burdenPercentile 29.6 activityPercentile 29.6 ranking row 2600590
11	=	Malignant Uterine Corpus Neoplasm	0	63	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4160 formula percentile(mortality_count) − percentile(active_trials) activity 411 burdenPercentile 51.9 activityPercentile 51.9 ranking row 2600592
16	=	Malignant Salivary Gland Neoplasm	-3.7	44.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 300 formula percentile(mortality_count) − percentile(active_trials) activity 63 burdenPercentile 7.4 activityPercentile 11.1 ranking row 2600593
17	=	Malignant Hypopharyngeal Neoplasm	-3.7	40.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 53 formula percentile(mortality_count) − percentile(active_trials) activity 53 burdenPercentile 0 activityPercentile 3.7 ranking row 2600594
18	=	Malignant Central Nervous System Neoplasm	-7.4	37	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 6978 formula percentile(mortality_count) − percentile(active_trials) activity 823 burdenPercentile 70.4 activityPercentile 77.8 ranking row 2600595
18	=	Multiple Myeloma	-7.4	37	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 5523 formula percentile(mortality_count) − percentile(active_trials) activity 814 burdenPercentile 66.7 activityPercentile 74.1 ranking row 2600596
20	=	Malignant Mesothelioma	-7.4	29.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 566 formula percentile(mortality_count) − percentile(active_trials) activity 96 burdenPercentile 18.5 activityPercentile 25.9 ranking row 2600597
21	=	Leukemia	-7.4	25.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 10022 formula percentile(mortality_count) − percentile(active_trials) activity 1769 burdenPercentile 81.5 activityPercentile 88.9 ranking row 2600598
21	=	Malignant Gastric Neoplasm	-7.4	25.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4525 formula percentile(mortality_count) − percentile(active_trials) activity 652 burdenPercentile 59.3 activityPercentile 66.7 ranking row 2600599
23	=	Malignant Liver Neoplasm	-11.1	18.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 8075 formula percentile(mortality_count) − percentile(active_trials) activity 906 burdenPercentile 74.1 activityPercentile 85.2 ranking row 2600600
24	=	Non-Hodgkin Lymphoma	-14.8	14.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 9102 formula percentile(mortality_count) − percentile(active_trials) activity 2168 burdenPercentile 77.8 activityPercentile 92.6 ranking row 2600601
25	=	Malignant Cervical Neoplasm	-14.9	11.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4115 formula percentile(mortality_count) − percentile(active_trials) activity 505 burdenPercentile 44.4 activityPercentile 59.3 ranking row 2600602
26	=	Hodgkin Lymphoma	-18.5	7.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 444 formula percentile(mortality_count) − percentile(active_trials) activity 179 burdenPercentile 14.8 activityPercentile 33.3 ranking row 2600603
27	=	Malignant Esophageal Neoplasm	-26	3.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 2982 formula percentile(mortality_count) − percentile(active_trials) activity 518 burdenPercentile 37 activityPercentile 63 ranking row 2600604
28	=	Malignant Nasopharyngeal Neoplasm	-37	0	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 180 formula percentile(mortality_count) − percentile(active_trials) activity 261 burdenPercentile 3.7 activityPercentile 40.7 ranking row 2600605

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 01ad7156f800ee2ec83d7d0a

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(active_trials)
Version: ci-trial-gap-v1
Scope: USA · Female · all ages · 2014 · top-level cancers
Scope key: geo=USA|sex=female|age=all|year=2014|level=top
Eligible entities: 28
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 01ad7156f800ee2ec83d7d0a
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality clinicaltrials cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
active_trials
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.