Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Trial Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Colon Neoplasm	+55.6	100	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 20845 formula percentile(mortality_count) − percentile(active_trials) activity 225 burdenPercentile 92.6 activityPercentile 37 ranking row 2598823
2	=	Malignant Vulvar Neoplasm	+25.9	96.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 1022 formula percentile(mortality_count) − percentile(active_trials) activity 54 burdenPercentile 33.3 activityPercentile 7.4 ranking row 2598824
3	=	Cutaneous Melanoma	+18.5	92.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3127 formula percentile(mortality_count) − percentile(active_trials) activity 78 burdenPercentile 40.7 activityPercentile 22.2 ranking row 2598825
4	=	Malignant Ovarian Neoplasm	+14.8	88.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 14346 formula percentile(mortality_count) − percentile(active_trials) activity 684 burdenPercentile 85.2 activityPercentile 70.4 ranking row 2598826
5	=	Malignant Bladder Neoplasm	+11.2	85.2	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4420 formula percentile(mortality_count) − percentile(active_trials) activity 346 burdenPercentile 55.6 activityPercentile 44.4 ranking row 2598827
6	=	Malignant Vaginal Neoplasm	+11.1	81.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 428 formula percentile(mortality_count) − percentile(active_trials) activity 31 burdenPercentile 11.1 activityPercentile 0 ranking row 2598828
7	=	Malignant Laryngeal Neoplasm	+11.1	77.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 784 formula percentile(mortality_count) − percentile(active_trials) activity 66 burdenPercentile 25.9 activityPercentile 14.8 ranking row 2598829
8	=	Malignant Pancreatic Neoplasm	+7.4	74.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 18463 formula percentile(mortality_count) − percentile(active_trials) activity 904 burdenPercentile 88.9 activityPercentile 81.5 ranking row 2598830
9	=	Malignant Kidney Neoplasm	+7.4	70.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4927 formula percentile(mortality_count) − percentile(active_trials) activity 453 burdenPercentile 63 activityPercentile 55.6 ranking row 2598831
10	=	Malignant Rectal Neoplasm	+3.8	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4134 formula percentile(mortality_count) − percentile(active_trials) activity 386 burdenPercentile 51.9 activityPercentile 48.1 ranking row 2598832
11	=	Malignant Anal Neoplasm	+3.7	63	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 518 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 22.2 activityPercentile 18.5 ranking row 2598833
12	=	Malignant Breast Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 40931 formula percentile(mortality_count) − percentile(active_trials) activity 2627 burdenPercentile 96.3 activityPercentile 96.3 ranking row 2598834
12	=	Malignant Lung Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 70217 formula percentile(mortality_count) − percentile(active_trials) activity 2644 burdenPercentile 100 activityPercentile 100 ranking row 2598835
12	=	Malignant Thyroid Gland Neoplasm	0	59.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 959 formula percentile(mortality_count) − percentile(active_trials) activity 176 burdenPercentile 29.6 activityPercentile 29.6 ranking row 2598836
15	=	Malignant Salivary Gland Neoplasm	-3.7	48.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 269 formula percentile(mortality_count) − percentile(active_trials) activity 63 burdenPercentile 7.4 activityPercentile 11.1 ranking row 2598837
16	=	Malignant Hypopharyngeal Neoplasm	-3.7	44.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 62 formula percentile(mortality_count) − percentile(active_trials) activity 53 burdenPercentile 0 activityPercentile 3.7 ranking row 2598838
17	=	Malignant Central Nervous System Neoplasm	-7.4	40.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 6363 formula percentile(mortality_count) − percentile(active_trials) activity 823 burdenPercentile 70.4 activityPercentile 77.8 ranking row 2598839
17	=	Multiple Myeloma	-7.4	40.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 5246 formula percentile(mortality_count) − percentile(active_trials) activity 814 burdenPercentile 66.7 activityPercentile 74.1 ranking row 2598840
19	=	Malignant Mesothelioma	-7.4	33.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 514 formula percentile(mortality_count) − percentile(active_trials) activity 96 burdenPercentile 18.5 activityPercentile 25.9 ranking row 2598841
20	=	Leukemia	-7.4	29.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 9975 formula percentile(mortality_count) − percentile(active_trials) activity 1769 burdenPercentile 81.5 activityPercentile 88.9 ranking row 2598842
20	=	Malignant Gastric Neoplasm	-7.4	29.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4491 formula percentile(mortality_count) − percentile(active_trials) activity 652 burdenPercentile 59.3 activityPercentile 66.7 ranking row 2598843
22	=	Malignant Uterine Corpus Neoplasm	-7.5	22.2	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3714 formula percentile(mortality_count) − percentile(active_trials) activity 411 burdenPercentile 44.4 activityPercentile 51.9 ranking row 2598844
23	=	Malignant Liver Neoplasm	-11.1	18.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 6982 formula percentile(mortality_count) − percentile(active_trials) activity 906 burdenPercentile 74.1 activityPercentile 85.2 ranking row 2598845
24	=	Malignant Cervical Neoplasm	-11.2	14.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4092 formula percentile(mortality_count) − percentile(active_trials) activity 505 burdenPercentile 48.1 activityPercentile 59.3 ranking row 2598846
25	=	Non-Hodgkin Lymphoma	-14.8	11.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 9013 formula percentile(mortality_count) − percentile(active_trials) activity 2168 burdenPercentile 77.8 activityPercentile 92.6 ranking row 2598847
26	=	Hodgkin Lymphoma	-18.5	7.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 480 formula percentile(mortality_count) − percentile(active_trials) activity 179 burdenPercentile 14.8 activityPercentile 33.3 ranking row 2598848
27	=	Malignant Esophageal Neoplasm	-26	3.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 2932 formula percentile(mortality_count) − percentile(active_trials) activity 518 burdenPercentile 37 activityPercentile 63 ranking row 2598849
28	=	Malignant Nasopharyngeal Neoplasm	-37	0	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 183 formula percentile(mortality_count) − percentile(active_trials) activity 261 burdenPercentile 3.7 activityPercentile 40.7 ranking row 2598850

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 97e3f77a840f61c7502d5536

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(active_trials)
Version: ci-trial-gap-v1
Scope: USA · Female · all ages · 2011 · top-level cancers
Scope key: geo=USA|sex=female|age=all|year=2011|level=top
Eligible entities: 28
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 97e3f77a840f61c7502d5536
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality clinicaltrials cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
active_trials
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

Download CSV (with attribution)

Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.