Ranking · Unmet Need

Trial Gap Index

Burden percentile minus active-trial percentile within the same scope. Positive values flag cancers with high mortality burden but comparatively few active trials. A quantitative signal, not an accusation (CLAUDE.md §324). Caveat (Phase 1): trial counts aggregate a cancer and its NCIt descendants only; registrations phrased at a broader level (e.g. "colorectal cancer" for colon and rectal cancer) are attributed to the broader entity, which can overstate the gap of narrower top-level sites.

Computedci-trial-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Trial Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Colon Neoplasm	+55.6	100	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 25169 formula percentile(mortality_count) − percentile(active_trials) activity 225 burdenPercentile 92.6 activityPercentile 37 ranking row 2592388
2	=	Malignant Vulvar Neoplasm	+18.5	96.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 752 formula percentile(mortality_count) − percentile(active_trials) activity 54 burdenPercentile 25.9 activityPercentile 7.4 ranking row 2592389
3	=	Malignant Laryngeal Neoplasm	+18.5	92.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 820 formula percentile(mortality_count) − percentile(active_trials) activity 66 burdenPercentile 33.3 activityPercentile 14.8 ranking row 2592390
4	=	Cutaneous Melanoma	+14.8	88.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 2828 formula percentile(mortality_count) − percentile(active_trials) activity 78 burdenPercentile 37 activityPercentile 22.2 ranking row 2592391
4	=	Malignant Vaginal Neoplasm	+14.8	88.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 405 formula percentile(mortality_count) − percentile(active_trials) activity 31 burdenPercentile 14.8 activityPercentile 0 ranking row 2592392
6	=	Malignant Ovarian Neoplasm	+14.8	81.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 14060 formula percentile(mortality_count) − percentile(active_trials) activity 684 burdenPercentile 85.2 activityPercentile 70.4 ranking row 2592393
7	=	Malignant Bladder Neoplasm	+7.5	77.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3839 formula percentile(mortality_count) − percentile(active_trials) activity 346 burdenPercentile 51.9 activityPercentile 44.4 ranking row 2592394
8	=	Malignant Pancreatic Neoplasm	+7.4	74.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 15094 formula percentile(mortality_count) − percentile(active_trials) activity 904 burdenPercentile 88.9 activityPercentile 81.5 ranking row 2592395
9	=	Malignant Kidney Neoplasm	+3.7	70.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4487 formula percentile(mortality_count) − percentile(active_trials) activity 453 burdenPercentile 59.3 activityPercentile 55.6 ranking row 2592396
10	=	Malignant Breast Neoplasm	0	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 41872 formula percentile(mortality_count) − percentile(active_trials) activity 2627 burdenPercentile 96.3 activityPercentile 96.3 ranking row 2592397
10	=	Malignant Gastric Neoplasm	0	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 5317 formula percentile(mortality_count) − percentile(active_trials) activity 652 burdenPercentile 66.7 activityPercentile 66.7 ranking row 2592398
10	=	Malignant Lung Neoplasm	0	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 65016 formula percentile(mortality_count) − percentile(active_trials) activity 2644 burdenPercentile 100 activityPercentile 100 ranking row 2592399
10	=	Malignant Rectal Neoplasm	0	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3781 formula percentile(mortality_count) − percentile(active_trials) activity 386 burdenPercentile 48.1 activityPercentile 48.1 ranking row 2592401
10	=	Malignant Thyroid Gland Neoplasm	0	66.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 778 formula percentile(mortality_count) − percentile(active_trials) activity 176 burdenPercentile 29.6 activityPercentile 29.6 ranking row 2592400
15	=	Multiple Myeloma	-3.7	48.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 5318 formula percentile(mortality_count) − percentile(active_trials) activity 814 burdenPercentile 70.4 activityPercentile 74.1 ranking row 2592402
16	=	Malignant Cervical Neoplasm	-3.7	44.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4200 formula percentile(mortality_count) − percentile(active_trials) activity 505 burdenPercentile 55.6 activityPercentile 59.3 ranking row 2592403
17	=	Malignant Salivary Gland Neoplasm	-3.7	40.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 244 formula percentile(mortality_count) − percentile(active_trials) activity 63 burdenPercentile 7.4 activityPercentile 11.1 ranking row 2592404
18	=	Malignant Hypopharyngeal Neoplasm	-3.7	37	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 72 formula percentile(mortality_count) − percentile(active_trials) activity 53 burdenPercentile 0 activityPercentile 3.7 ranking row 2592405
19	=	Malignant Central Nervous System Neoplasm	-3.7	33.3	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 5644 formula percentile(mortality_count) − percentile(active_trials) activity 823 burdenPercentile 74.1 activityPercentile 77.8 ranking row 2592406
20	=	Malignant Mesothelioma	-7.4	29.6	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 459 formula percentile(mortality_count) − percentile(active_trials) activity 96 burdenPercentile 18.5 activityPercentile 25.9 ranking row 2592407
21	=	Malignant Anal Neoplasm	-7.4	25.9	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 298 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 11.1 activityPercentile 18.5 ranking row 2592408
22	=	Malignant Uterine Corpus Neoplasm	-7.5	22.2	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 3139 formula percentile(mortality_count) − percentile(active_trials) activity 411 burdenPercentile 44.4 activityPercentile 51.9 ranking row 2592409
23	=	Non-Hodgkin Lymphoma	-11.1	18.5	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 10917 formula percentile(mortality_count) − percentile(active_trials) activity 2168 burdenPercentile 81.5 activityPercentile 92.6 ranking row 2592410
24	=	Hodgkin Lymphoma	-11.1	14.8	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 601 formula percentile(mortality_count) − percentile(active_trials) activity 179 burdenPercentile 22.2 activityPercentile 33.3 ranking row 2592411
25	=	Leukemia	-11.1	11.1	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 9594 formula percentile(mortality_count) − percentile(active_trials) activity 1769 burdenPercentile 77.8 activityPercentile 88.9 ranking row 2592412
26	=	Malignant Liver Neoplasm	-22.2	7.4	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 4740 formula percentile(mortality_count) − percentile(active_trials) activity 906 burdenPercentile 63 activityPercentile 85.2 ranking row 2592413
27	=	Malignant Esophageal Neoplasm	-22.3	3.7	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 2953 formula percentile(mortality_count) − percentile(active_trials) activity 518 burdenPercentile 40.7 activityPercentile 63 ranking row 2592414
28	=	Malignant Nasopharyngeal Neoplasm	-37	0	Medium confidence	cdc-uscs clinicaltrials cdc-wonder seer iarc-globocan	inputs deaths 206 formula percentile(mortality_count) − percentile(active_trials) activity 261 burdenPercentile 3.7 activityPercentile 40.7 ranking row 2592415

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 62b4ecb46805f83a7061d048

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(active_trials)
Version: ci-trial-gap-v1
Scope: USA · Female · all ages · 2000 · top-level cancers
Scope key: geo=USA|sex=female|age=all|year=2000|level=top
Eligible entities: 28
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 62b4ecb46805f83a7061d048
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality clinicaltrials cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
active_trials
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

Download CSV (with attribution)

Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.