Toripalimab

monoclonal antibody

Identifier: CI-DRUG-00000598
Entity page: /drug/toripalimab ↗
Edges: 488

Neighbours: 24 cancers1 genes1 variants10 trials3 approvals
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Toripalimab approved for …APPROVED_FOR6 of 3
→ approved for	Nasopharyngeal Carcinomasubtype	supports	FDA ORIG	Nasopharyngeal Carcinoma	1	Regulatory	openfda	graph →
→ approved for	Esophageal Squamous Cell Carcinomasubtype	supports	EMA indication text

Toripalimab predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	High	sensitivity	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →

Toripalimab predicts response to …PREDICTS_RESPONSE_TO1 of 1

← predicts response to

High

sensitivity

Lung Non-Small Cell Carcinoma

Curated

Toripalimab investigated for …INVESTIGATED_FOR15 of 40show all (up to 200)
→ investigated for	Lung Non-Small Cell Carcinomasubtype	supports	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Nasopharyngeal Carcinomasubtype	unknown	4	Nasopharyngeal Carcinoma	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Adenocarcinomahistology	unknown	3	Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Hodgkin Lymphomahematologic_malignancy	unknown	3	Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Neuroendocrine Carcinomasubtype	unknown	3	Neuroendocrine Carcinoma	1	Curated	chembl	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	3	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Nasopharyngeal Neoplasmsubtype	unknown	3	Nasopharyngeal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	3	Melanoma	1	Curated	chembl	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	unknown	3	Lung Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Esophageal Neoplasmcancer_family	unknown	3	Esophageal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	3	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	3	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Cholangiocarcinomasubtype	unknown	3	Cholangiocarcinoma	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	3	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →

Toripalimab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 108show all (up to 200)
→ investigated in trials for	Solid Neoplasm 32 trials (16 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	32	Observed	clinicaltrials	graph →
→ investigated in trials for	Hepatocellular Carcinoma 25 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	25	Observed	clinicaltrials	graph →
→ investigated in trials for	Nasopharyngeal Carcinomasubtype 24 trials (20 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Nasopharyngeal Carcinoma	24	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 23 trials (11 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	23	Observed	clinicaltrials	graph →
→ investigated in trials for	Esophageal Squamous Cell Carcinomasubtype 18 trials (10 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Esophageal Squamous Cell Carcinoma	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Head and Neck Squamous Cell Carcinoma 13 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Head and Neck Squamous Cell Carcinoma	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Small Cell Carcinomasubtype 12 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 12 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Melanomacancer_family 10 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Melanoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Triple-Negative Breast Carcinomamolecular_subtype 9 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Triple-Negative Breast Carcinoma	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 8 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 8 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Urothelial Carcinoma 8 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Urothelial Carcinoma	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasm 7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Cervical Neoplasm 6 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Cervical Neoplasm	6	Observed	clinicaltrials	graph →

Toripalimab studied in …STUDIED_INderived10 of 335show all (up to 200)
→ studied in	NCT07559929Phase 1/Phase 2 · recruiting A Study of DXC006 With Immune Checkpoint Inhibitors or Platinum for Small Cell Lung Cancer. · 335 trials list this drug (191 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06088004Phase 1/Phase 2 · recruiting Phase Ⅰ/Ⅱ Clinical Study to Evaluate ABO2011 in Advanced Solid Tumors · 335 trials list this drug (191 active)	—	—	Adult Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07836049Phase 2 · not yet recruiting PhII Study of Toripalimab Followed by Definitive CRT & Adjuvant Toripalimab in Locally Advanced ESCC · 335 trials list this drug (191 active)	—	—	Esophageal Squamous Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07835035Phase 1 · recruiting Rimegepant Plus Toripalimab in Advanced Urothelial Carcinoma After Failure of Standard Therapy · 335 trials list this drug (191 active)	—	—	Urothelial Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04387084Phase 1 · active not recruiting Short-term Fasting Prior to PD-1/PD-L1 Inhibitor Therapy for of Advanced or Metastatic Skin Malignancy · 335 trials list this drug (191 active)	—	—	Malignant Skin Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07562841Phase 1 · recruiting Au-TMP and Radiotherapy for Advanced Melanoma With Anti-PD-1 Therapy · 335 trials list this drug (191 active)	—	—	Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07823270Phase 2 · not yet recruiting Neoadjuvant Sacituzumab Tirumotecan Plus Toripalimab in Locally Advanced Esophageal Squamous Cell Carcinoma · 335 trials list this drug (191 active)	—	—	Esophageal Squamous Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07823348Phase 3 · not yet recruiting JS207 Plus JS007 Versus Toripalimab Plus Bevacizumab as First-Line Treatment for Advanced Liver Cancer · 335 trials list this drug (191 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07819578Phase 2 · not yet recruiting Toripalimab Plus Sacituzumab Tirumotecan as Neoadjuvant Therapy for Resectable NSCLC · 335 trials list this drug (191 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07816770Phase 2 · not yet recruiting MANTIS-RCC: Toripalimab-Axitinib Induction in TLS-Positive Advanced Non-Clear Cell and Renal Medullary Carcinomas · 335 trials list this drug (191 active)	—	—	Non-Clear Cell Renal Cell Carcinoma,Renal Medullary Carcinoma	1	Observed	clinicaltrials	graph →

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