Chronic Lymphocytic Leukemia

Curated

in context · predicts response to

TP53 Mutationother → predicts response to Alemtuzumab

sensitivity

Curated

in context · predicts response to

BTK T316ASNV → predicts response to Ibrutinib

resistance

Curated

in context · predicts response to

ATM D1930VSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

BCL2 G101VSNV → predicts response to Venetoclax

resistance

Curated

in context · predicts response to

ATM C2488YSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM A2062VSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM D1682HSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM F2732VSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM L2427PSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM E2187*SNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM F1025LSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM K293*SNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM c.7515+1_2del → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM c.7089+1del → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM c.902-1G>TSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM R3008CSNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM T2666ASNV → predicts response to Doxorubicin

resistance

Curated

in context · predicts response to

ATM Mutationother → predicts response to Doxorubicin

resistance

Curated

Chronic Lymphocytic Leukemia prognostic in …PROGNOSTIC_IN15 of 17show all (up to 200)
← prognostic in	SF3B1 Mutationother	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	ATM Mutationother	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	NOTCH1 Mutationother	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	TP53 Mutationother	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	TP53 Mutationother 5 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	5	Curated	civic	graph →
← prognostic in	SF3B1 Mutationother 3 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	3	Curated	civic	graph →
← prognostic in	NOTCH1 P2514FSindel 2 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	2	Curated	civic	graph →
← prognostic in	MYD88 L265PSNV	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	BIRC3 TRUNCATING MUTATIONindel	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	NOTCH1 Mutationother	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	High	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	ATM Mutationother	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	POT1 MUTATIONother	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	ATM Underexpressionexpression	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← prognostic in	BTK MUTATIONother	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →

Chronic Lymphocytic Leukemia prognostic in …PROGNOSTIC_IN15 of 17show all (up to 200)

← prognostic in

SF3B1 Mutationother

supports

Curated

← prognostic in

ATM Mutationother

supports

Curated

← prognostic in

NOTCH1 Mutationother

supports

Curated

← prognostic in

TP53 Mutationother

supports

Curated

← prognostic in

TP53 Mutationother

5 source records aggregated

supports

Curated

← prognostic in

SF3B1 Mutationother

3 source records aggregated

supports

Curated

← prognostic in

NOTCH1 P2514FSindel

2 source records aggregated

supports

Curated

← prognostic in

MYD88 L265PSNV

supports

Curated

← prognostic in

BIRC3 TRUNCATING MUTATIONindel

supports

Curated

← prognostic in

NOTCH1 Mutationother

supports

Curated

← prognostic in

High

supports

Curated

← prognostic in

ATM Mutationother

supports

Curated

← prognostic in

POT1 MUTATIONother

supports

Curated

← prognostic in

ATM Underexpressionexpression

supports

Curated

← prognostic in

BTK MUTATIONother

supports

Curated

Chronic Lymphocytic Leukemia associated with …ASSOCIATED_WITH15 of 17show all (up to 200)
← associated with	SF3B1	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	ATM	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	NOTCH1	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	TP53	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	TP53 6 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	6	Curated	civic	graph →
← associated with	NOTCH1 3 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	3	Curated	civic	graph →
← associated with	BTK 3 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	3	Curated	civic	graph →
← associated with	SF3B1 3 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	3	Curated	civic	graph →
← associated with	ATM 2 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	2	Curated	civic	graph →
← associated with	MYD88	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	BIRC3	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	POT1	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	GNAS	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	PLCG2	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← associated with	BTK	supports	C	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →

Chronic Lymphocytic Leukemia associated with …ASSOCIATED_WITH15 of 17show all (up to 200)

← associated with

SF3B1

supports

Curated

← associated with

ATM

supports

Curated

← associated with

NOTCH1

supports

Curated

← associated with

TP53

supports

Curated

← associated with

TP53

6 source records aggregated

supports

Curated

← associated with

NOTCH1

3 source records aggregated

supports

Curated

← associated with

BTK

3 source records aggregated

supports

Curated

← associated with

SF3B1

3 source records aggregated

supports

Curated

← associated with

ATM

2 source records aggregated

supports

Curated

← associated with

MYD88

supports

Curated

← associated with

BIRC3

supports

Curated

← associated with

POT1

supports

Curated

← associated with

GNAS

supports

Curated

← associated with

PLCG2

supports

Curated

← associated with

BTK

supports

Curated

Chronic Lymphocytic Leukemia investigated for …INVESTIGATED_FOR15 of 100show all (up to 200)
← investigated for	Ibrutinibsmall_molecule 2 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	2	Curated	civic	graph →
← investigated for	Alemtuzumabmonoclonal_antibody	supports	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← investigated for	Venetoclaxsmall_molecule	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Rituximabmonoclonal_antibody	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Ofatumumabmonoclonal_antibody	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Obinutuzumabmonoclonal_antibody	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Idelalisibsmall_molecule	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Ibrutinibsmall_molecule	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Duvelisibsmall_molecule	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Bendamustinesmall_molecule	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Alemtuzumabmonoclonal_antibody	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Acalabrutinibsmall_molecule	unknown	4	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Ibrutinibsmall_molecule	supports	C	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
← investigated for	Zanubrutinibsmall_molecule	unknown	3	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →
← investigated for	Vincristinesmall_molecule	unknown	3	Chronic Lymphocytic Leukemia	1	Curated	chembl	graph →

Chronic Lymphocytic Leukemia investigated for …INVESTIGATED_FOR15 of 100show all (up to 200)

← investigated for

Ibrutinibsmall_molecule

2 source records aggregated

supports

Curated

← investigated for

Alemtuzumabmonoclonal_antibody

supports

Curated

← investigated for

Venetoclaxsmall_molecule

unknown

Curated

← investigated for

Rituximabmonoclonal_antibody

unknown

Curated

← investigated for

Ofatumumabmonoclonal_antibody

unknown

Curated

← investigated for

Obinutuzumabmonoclonal_antibody

unknown

Curated

← investigated for

Idelalisibsmall_molecule

unknown

Curated

← investigated for

Ibrutinibsmall_molecule

unknown

Curated

← investigated for

Duvelisibsmall_molecule

unknown

Curated

← investigated for

Bendamustinesmall_molecule

unknown

Curated

← investigated for

Alemtuzumabmonoclonal_antibody

unknown

Curated

← investigated for

Acalabrutinibsmall_molecule

unknown

Curated

← investigated for

Ibrutinibsmall_molecule

supports

Curated

← investigated for

Zanubrutinibsmall_molecule

unknown

Curated

← investigated for

Vincristinesmall_molecule

unknown

Curated

Chronic Lymphocytic Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 146show all (up to 200)
→ investigated in trials for	Fludarabinesmall_molecule 157 trials (30 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	157	Observed	clinicaltrials	graph →
→ investigated in trials for	Rituximabmonoclonal_antibody 153 trials (31 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	153	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 125 trials (32 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	125	Observed	clinicaltrials	graph →
→ investigated in trials for	Venetoclaxsmall_molecule 96 trials (56 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	96	Observed	clinicaltrials	graph →
→ investigated in trials for	Ibrutinibsmall_molecule 86 trials (32 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	86	Observed	clinicaltrials	graph →
→ investigated in trials for	Obinutuzumabmonoclonal_antibody 85 trials (46 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	85	Observed	clinicaltrials	graph →
→ investigated in trials for	Lenalidomidesmall_molecule 57 trials (4 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	57	Observed	clinicaltrials	graph →
→ investigated in trials for	Bendamustinesmall_molecule 56 trials (13 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	56	Observed	clinicaltrials	graph →
→ investigated in trials for	Acalabrutinibsmall_molecule 48 trials (35 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	48	Observed	clinicaltrials	graph →
→ investigated in trials for	Alemtuzumabmonoclonal_antibody 29 trials (1 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Chlorambucilsmall molecule 28 trials (4 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	28	Observed	clinicaltrials	graph →
→ investigated in trials for	Idelalisibsmall_molecule 28 trials (4 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	28	Observed	clinicaltrials	graph →
→ investigated in trials for	Ofatumumabmonoclonal_antibody 28 trials (1 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	28	Observed	clinicaltrials	graph →
→ investigated in trials for	Zanubrutinibsmall_molecule 26 trials (22 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	26	Observed	clinicaltrials	graph →
→ investigated in trials for	Pirtobrutinibsmall_molecule 24 trials (21 active) · roll-up of the cancer and its descendants	—	—	Chronic Lymphocytic Leukemia	24	Observed	clinicaltrials	graph →

Chronic Lymphocytic Leukemia investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 146show all (up to 200)

→ investigated in trials for

Fludarabinesmall_molecule

157 trials (30 active) · roll-up of the cancer and its descendants

—

157

Observed

→ investigated in trials for

Rituximabmonoclonal_antibody

153 trials (31 active) · roll-up of the cancer and its descendants

—

153

Observed

→ investigated in trials for

Cyclophosphamidesmall molecule

125 trials (32 active) · roll-up of the cancer and its descendants

—

125

Observed

→ investigated in trials for

Venetoclaxsmall_molecule

96 trials (56 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Ibrutinibsmall_molecule

86 trials (32 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Obinutuzumabmonoclonal_antibody

85 trials (46 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Lenalidomidesmall_molecule

57 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Bendamustinesmall_molecule

56 trials (13 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Acalabrutinibsmall_molecule

48 trials (35 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Alemtuzumabmonoclonal_antibody

29 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Chlorambucilsmall molecule

28 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Idelalisibsmall_molecule

28 trials (4 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Ofatumumabmonoclonal_antibody

28 trials (1 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Zanubrutinibsmall_molecule

26 trials (22 active) · roll-up of the cancer and its descendants

—

Observed

→ investigated in trials for

Pirtobrutinibsmall_molecule

24 trials (21 active) · roll-up of the cancer and its descendants

—

Observed

Chronic Lymphocytic Leukemia studied in …STUDIED_INderived10 of 1,256show all (up to 200)
→ studied in	NCT07796373Phase 2 · not yet recruiting Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 Inhibitor · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07847957Phase 1/Phase 2 · not yet recruiting Roginolisib Plus Obinutuzumab + Venetoclax in R/R CLL · condition mapped ALIAS · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT00923507recruiting Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL) · condition mapped ALIAS · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01087294Phase 1 · completed Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation · condition mapped ALIAS · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT02473757enrolling by invitation Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell Studies · condition mapped ALIAS · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03462719Phase 3 · active not recruiting A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) · condition mapped ALIAS · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT03560752Phase 1 · active not recruiting CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04269902Phase 3 · recruiting Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05006716Phase 1/Phase 2 · recruiting A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05424822Phase 1 · active not recruiting A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) · condition mapped ALIAS · 1,256 trials mapped (327 active)	—	—	Chronic Lymphocytic Leukemia	1	Observed	clinicaltrials	graph →

Chronic Lymphocytic Leukemia studied in …STUDIED_INderived10 of 1,256show all (up to 200)

→ studied in

NCT07796373Phase 2 · not yet recruiting

Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 Inhibitor · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT07847957Phase 1/Phase 2 · not yet recruiting

Roginolisib Plus Obinutuzumab + Venetoclax in R/R CLL · condition mapped ALIAS · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT00923507recruiting

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL) · condition mapped ALIAS · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT01087294Phase 1 · completed

Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation · condition mapped ALIAS · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT02473757enrolling by invitation

Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell Studies · condition mapped ALIAS · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT03462719Phase 3 · active not recruiting

A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) · condition mapped ALIAS · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT03560752Phase 1 · active not recruiting

CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT04269902Phase 3 · recruiting

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT05006716Phase 1/Phase 2 · recruiting

A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies · condition mapped ONTOLOGY_EXACT · 1,256 trials mapped (327 active)

—

Observed

→ studied in

NCT05424822Phase 1 · active not recruiting

A Study of JNJ-80948543, a T-cell Redirecting CD79b x CD20 x CD3 Trispecific Antibody, in Participants With Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) · condition mapped ALIAS · 1,256 trials mapped (327 active)

—

Observed