BCL2 G101V

CI-VAR-00001549Explore in graph →ENST00000398117.1:c.302G>TCIViC 2960

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Lymphocytic Leukemia6
BCL2 G101V	Venetoclax	Predictive	B	Supports Resistance	4	submitted	EID8174 This study identified G101V mutation in BCL2 emerged in 7 out of 15 patients with CLL progression treated with Venetoclax. In addition, this study demonstrated that the G101V mutation impairs binding … (full text at CIViC) PMID 30514704 · Blombery et al., 2019 · Open in CIViC	civic
BCL2 G101V	Venetoclax	Predictive	C	Supports Resistance	4	submitted	EID7970 Four of six heavily pretreated, high-risk CLL patients with a 17p deletion from the phase 2 trial M13-9824 with continuous venetoclax treatment, who were treated with venetoclax for a period longer th… (full text at CIViC) PMID 31004028 · Tausch et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma1
BCL2 G101V	Venetoclax	Predictive	C	Supports Resistance	2	accepted	EID8185 The effective cohort in this study was 11 CLL patients who were first treated with ibrutinib and then on progression treated with venetoclax until progression. Patient samples were sequenced before an… (full text at CIViC) PMID 32232486 · Lucas et al., 2020 · Open in CIViC	civic