SF3B1 Mutation

CI-VAR-00002655Explore in graph →CIViC 215

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Lymphocytic Leukemia4
SF3B1 Mutation	(prognostic)	Prognostic	A	Supports Poor Outcome	5	accepted	EID1540 In a study of 406 previously untreated CLL cases, a multivariate analysis indicated SF3B1 mutations (N=51) were significantly associated with reduced time to first treatment (HR: 1.73; 95%CI: 1.05-2.8… (full text at CIViC) PMID 26837699 · Nadeu et al., 2016 · Open in CIViC	civic
SF3B1 Mutation	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID510 In patients with chronic lymphocytic leukemia, those with mutations in SF3B1 had shorter time to treatment, progression-free survival, and overall survival. A majority of the mutations are in the C-te… (full text at CIViC) PMID 23568491 · Wan et al., 2013 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Myelodysplastic Syndrome3
SF3B1 Mutation	(prognostic)	Prognostic	B	Supports Better Outcome	3	accepted	EID352 Patients with SF3B1 mutations had a statistically significant longer overall survival as well as event free-survival. Both before and after adjustment for age, karyotype and sex. PMID 21995386 · Papaemmanuil et al., 2011 · Open in CIViC	civic
SF3B1 Mutation	(prognostic)	Prognostic	B	Supports Better Outcome	3	submitted	EID5931 There was a significant association of SF3B1 mutations with the presence of ring sideroblasts (P < .001) and of mutant allele burden with their proportion (P = .002). The mutant gene had a positive pr… (full text at CIViC) PMID 21998214 · Malcovati et al., 2011 · Open in CIViC	civic
SF3B1 Mutation	(prognostic)	Prognostic	B	Supports Better Outcome	2	submitted	EID7135 From a cohort of 944 patients with myelodysplastic syndrome, 311 patients harboring SF3B1 mutations were identified. In univariate analysis of 875 patients with sufficient clinical outcomes data, SF3B… (full text at CIViC) PMID 24220272 · Haferlach et al., 2014 · Open in CIViC	civic