STAT3 NM_139276.3(STAT3):c.1492A>G (p.Ile498Val)

CI-VAR-00099307Explore in graph →p.Ile498ValNM_139276.3:c.1492A>GClinVar 542785 rs146620441

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
542785	Likely benign	criteria provided, multiple submitters, no conflicts	2	Hyper-IgE recurrent infection syndrome 1, autosomal dominant; STAT3 gain of function; STAT3-related disorder; Lung cancer	germline	6	Jan 27, 2026	clinvar