Publication
Somatic STAT3 mutations in large granular lymphocytic leukemia.
Authors not recorded
N Engl J Med2012PMID 22591296PMC3693860stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerT-Cell Large Granular Lymphocyte Leukemiacivic_curation1.00
- geneSTAT3civic_curation1.00
- variantSTAT3 SH2 DOMAIN MUTATIONcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 22591296
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| STAT3 SH2 DOMAIN MUTATION1 | ||||||||
| (diagnostic) | T-Cell Large Granular Lymphocyte Leukemia | Diagnostic | B | Supports Positive | 4 | accepted | EID957Mutations in the Src homology 2 (SH2) domain (exon 21) of STAT3 were found in 31 of 77 patients (40%) with large granular lymphocytic leukemia. Recurrent mutational hot spots included Y640F, D661V, D6… (full text at CIViC) PMID 22591296 · Koskela et al., 2012 · Open in CIViC | civic |