STAT3 NM_139276.3(STAT3):c.1852G>C (p.Gly618Arg)

CI-VAR-00197736Explore in graph →p.Gly618ArgNM_139276.3:c.1852G>CClinVar 1192236 rs2081548277

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1192236	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	EBV-Positive Inflammatory Follicular Dendritic Cell Sarcoma; STAT3 gain of function; Hyper-IgE recurrent infection syndrome 1, autosomal dominant; STAT3-related disorder	germline/somatic	6	Aug 07, 2025	clinvar