STAT3 NM_139276.3(STAT3):c.1919A>T (p.Tyr640Phe)

CI-VAR-00055429Explore in graph →p.Tyr640PheNM_139276.3:c.1919A>TClinVar 372521 rs769031989

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
372521	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	STAT3 gain of function; Hyper-IgE recurrent infection syndrome 1, autosomal dominant; Malignant lymphoma, large B-cell, diffuse; Neoplasm; EBV-positive nodal T- and NK-cell lymphoma; T-LGL Leukemia; STAT3-related disorder	germline/somatic	8	Nov 18, 2025	clinvar