T-Cell Large Granular Lymphocyte Leukemia — Variants & evidence

T-Cell Large Granular Lymphocyte Leukemia — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

1 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
STAT3 SH2 DOMAIN MUTATION1
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID957 Mutations in the Src homology 2 (SH2) domain (exon 21) of STAT3 were found in 31 of 77 patients (40%) with large granular lymphocytic leukemia. Recurrent mutational hot spots included Y640F, D661V, D6… (full text at CIViC) PMID 22591296 · Koskela et al., 2012 · Open in CIViC	civic

Data updated 10 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.