RIT1 F82L

CI-VAR-00001142Explore in graph →CIViC 3593

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
RIT1 F82L	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9834 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 F82L was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 F… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
Unmapped disease1unmapped disease
RIT1 F82L	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID9835 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 F82L-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.