Publication
Oncogenic RIT1 mutations in lung adenocarcinoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerLung Adenocarcinomacivic_curation1.00
- drugPictilisibcivic_curation1.00
- drugSelumetinibcivic_curation1.00
- geneRIT1civic_curation1.00
- variantRIT1 Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (12)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24469055
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| RIT1 A77P2 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID9830RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 A77P was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 A… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 2 | submitted | EID9832RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 A77P-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| RIT1 A77S2 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID9831RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 A77S was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 A… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 2 | submitted | EID9833RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 A77S-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| RIT1 F82L2 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID9834RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 F82L was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 F… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 2 | submitted | EID9835RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 F82L-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| RIT1 M90I2 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID9825RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 M90I was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 M… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | submitted | EID9826RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from NCI-H2110 with endogenous RIT1 M90I and RIT1-transduced PC6 lu… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| RIT1 Mutation1 | ||||||||
| Pictilisib + SelumetinibSubstitutes | Lung Adenocarcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID742RIT1 mutations were identified in approx. 2% of lung adenocarcinomas (5/87 in the "oncogene negative" samples of TCGA - no RIT1 mutations were observed in 143 samples with a known driver mutation). GD… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| RIT1 Q40L1 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | D | Does Not Support Oncogenicity | 3 | submitted | EID9829RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q40L was expressed in NIH3T3 cells and did not induce colony formation in soft agar greater tha… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| RIT1 Q79L2 | ||||||||
| (oncogenic) | Lung Adenocarcinoma | Oncogenic | D | Supports Oncogenicity | 3 | submitted | EID9827RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q79L, a known activating mutation, was expressed in NIH3T3 cells and induced colony formation i… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |
| (functional) | —UNRESOLVED | Functional | D | Supports Gain Of Function | 3 | submitted | EID9828RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 Q79L-transduced PC6 lung cancer cells showed strong activ… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC | civic |