RIT1 Q79L

CI-VAR-00003595Explore in graph →CIViC 3589

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
RIT1 Q79L	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9827 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q79L, a known activating mutation, was expressed in NIH3T3 cells and induced colony formation i… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
Unmapped disease1unmapped disease
RIT1 Q79L	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9828 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 Q79L-transduced PC6 lung cancer cells showed strong activ… (full text at CIViC) PMID 24469055 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.