MYH11 Fusion

CI-VAR-00001174Explore in graph →CIViC 431

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia3
CBFB::MYH11 Fusion	(prognostic)	Prognostic	B	Supports Better Outcome	4	rejected	EID1026 The CBFB-MYH11 fusion has been shown to be associated with favorable prognosis in patients with acute myeloid leukemia. PMID 22180162 · Estey, 2012 · Open in CIViC	civic
CBFB::MYH11 Fusion	(prognostic)	Prognostic	B	Supports Better Outcome	4	accepted	EID1027 The CBFB-MYH11 fusion has been shown to be associated with favorable prognosis in acute myeloid leukemia. PMID 22180162 · Estey, 2012 · Open in CIViC	civic
CBFB::MYH11 Fusion AND ETV6::ABL2 Fusion	(oncogenic)	Oncogenic	C

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH114
CBFB::MYH11 Fusion	(prognostic)	Prognostic	B	Supports Better Outcome	5	submitted	EID11788 This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c… (full text at CIViC) PMID 9746770 · Grimwade et al., 1998 · Open in CIViC	civic
CBFB::MYH11 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	5	accepted	EID11791 This is a Cancer and Leukemia Group B study on core binding factor (CBF) AML (2005): AML with RUNX1::RUNX1T1 (303 adult patients who received treatment) vs AML with CBFB::MYH11 (164 patients who recei… (full text at CIViC) PMID 16110030 · Marcucci et al., 2005 · Open in CIViC	civic
CBFB::MYH11 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	5	accepted	EID11792 A metanalysis study from the German AML Intergroup (2004) on AML-CBF included 8 German multicenter treatment trials enrolling patients with AML with RUNX1::RUNX1T1 (191 adult patients) and CBFB::MYH11… (full text at CIViC) PMID 15289486 · Schlenk et al., 2004 · Open in CIViC	civic
CBFB::MYH11 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID11793 A small study on 18 patients of AML with inv(16)(p13q22) [now known to correspond to CBFB::MYH11 fusion] identified abnormal eosinophils as a unique morphologic characteristic of this entity. 76.5% ac… (full text at CIViC) PMID 6577285 · Le Beau et al., 1983 · Open in CIViC	civic