MYH11 NM_002474.3(MYH11):c.5273G>A (p.Arg1758Gln)

CI-VAR-00006300Explore in graph →p.Arg1758GlnNM_002474.3:c.5273G>AClinVar 161316 rs142546324

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
161316	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Aortic aneurysm, familial thoracic 4; Familial thoracic aortic aneurysm and aortic dissection; MYH11-related disorder; Colon adenocarcinoma; Cervical cancer	germline	16	Jan 08, 2026	clinvar