Gene

KDR

kinase insert domain receptor

Explore in graph →CI-GENE-00006819HGNC:6307 ENSG00000128052 NCBI 3791 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (15)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–15 of 15 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KDR A1065T1
Sorafenib + SunitinibSubstitutes	Angiosarcoma	Predictive	D	Supports Sensitivity Response	3	accepted

Cohorts

Alteration frequency by cohort (153)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved153 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Lung Adenocarcinoma Met Organotropism (MSK, Cancer Cell 2023) luad_mskcc_2023_met_organotropism	Lung Adenocarcinoma	Ssm

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

KDR Mutation as a Novel Predictive Biomarker of Exceptional Response to Regorafenib in Metastatic Colorectal Cancer.
· Cureus · 2016 · PMID 27004155 · validated civic_curation pubmed
KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.
· Cancer Res · 2009 · PMID 19723655 · validated civic_curation pubmed
Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.
· Clin Cancer Res · 2018 · PMID 29588308 · validated civic_curation pubmed

KDR Amplification1
Pazopanib	Angiosarcoma	Predictive	C	Supports Sensitivity Response	3	submitted	EID7139 The angiosarcoma harbored amplifications of VEGFR2 (KDR) of 8 copies and VEGFR3 (FLT4) of 16 copies. The patient was initially treated with sorafenib, an inhibitor of VEGFR2, and developed progressive… (full text at CIViC) PMID 27160228 · Ravi et al., 2016 · Open in CIViC	civic

KDR Amplification1

Pazopanib

Angiosarcoma

Predictive

Supports Sensitivity Response

submitted

EID7139

The angiosarcoma harbored amplifications of VEGFR2 (KDR) of 8 copies and VEGFR3 (FLT4) of 16 copies. The patient was initially treated with sorafenib, an inhibitor of VEGFR2, and developed progressive… (full text at CIViC)

PMID 27160228 · Ravi et al., 2016 · Open in CIViC

civic

KDR D717V1
Sorafenib + SunitinibSubstitutes	Angiosarcoma	Predictive	D	Supports Sensitivity Response	3	accepted	EID1107 COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or D717V-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type ce… (full text at CIViC) PMID 19723655 · Antonescu et al., 2009 · Open in CIViC	civic

KDR D717V1

Sorafenib + SunitinibSubstitutes

Angiosarcoma

Predictive

Supports Sensitivity Response

accepted

EID1107

COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or D717V-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type ce… (full text at CIViC)

PMID 19723655 · Antonescu et al., 2009 · Open in CIViC

civic

KDR G800D1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9952 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR G800D1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9952

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR G800R1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9953 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800R caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR G800R1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9953

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800R caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR G843D1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9954 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G843D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR G843D1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9954

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G843D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR L840F1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9951 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) L840F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR L840F1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9951

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) L840F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR Overexpression2
Pazopanib	Neuroendocrine Tumor	Predictive	B	Supports Sensitivity Response	3	submitted	EID7854 Phase 2 study of pazopanib in pretreated advanced neuroendocrine tumors. Study found that patients with immunoexpression of VEGFR2 (KDR) above the median had longer PFS (12.6 months vs 9.1 months, P=… (full text at CIViC) PMID 26063633 · Grande et al., 2015 · Open in CIViC	civic
Sunitinib	Breast Angiosarcoma	Predictive	C	Supports Sensitivity Response	3	submitted	EID5910 gene expression assay performed earlier demonstrated a This case report of a patient with refractory breast angiosarcoma shows a potential therapeutic benefit of sunitinib due to the upregulation of V… (full text at CIViC) PMID 25639617 · Silva et al., 2015 · Open in CIViC	civic

KDR Overexpression2

Pazopanib

Neuroendocrine Tumor

Predictive

Supports Sensitivity Response

submitted

EID7854

Phase 2 study of pazopanib in pretreated advanced neuroendocrine tumors. Study found that patients with immunoexpression of VEGFR2 (KDR) above the median had longer PFS (12.6 months vs 9.1 months, P=… (full text at CIViC)

PMID 26063633 · Grande et al., 2015 · Open in CIViC

civic

Sunitinib

Breast Angiosarcoma

Predictive

Supports Sensitivity Response

submitted

EID5910

gene expression assay performed earlier demonstrated a This case report of a patient with refractory breast angiosarcoma shows a potential therapeutic benefit of sunitinib due to the upregulation of V… (full text at CIViC)

PMID 25639617 · Silva et al., 2015 · Open in CIViC

civic

KDR R1022Q1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9956 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1022Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR R1022Q1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9956

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1022Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR R1032Q2
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9957 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1032Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic
Axitinib + Cabozantinib + Dovitinib + LenvatinibSubstitutes	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	D	Supports Sensitivity Response	2	accepted	EID9339 R1032Q affects the gene's universal kinase catalytic motif. The authors found that injection of mice with COLO-320 cells that harbor this mutation resulted in tumor generation, indicating that this mu… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR R1032Q2

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9957

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1032Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

Axitinib + Cabozantinib + Dovitinib + LenvatinibSubstitutes

Malignant Colorectal NeoplasmCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID9339

R1032Q affects the gene's universal kinase catalytic motif. The authors found that injection of mice with COLO-320 cells that harbor this mutation resulted in tumor generation, indicating that this mu… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR R961W1
Regorafenib Anhydrous	Colorectal Adenocarcinoma	Predictive	C	Supports Sensitivity Response	1	accepted	EID1191 Case Report of a 84-year-old woman with stage IVb CRC after progression under 5-fluorouracil and bevacizumab. NGS revealed a frameshift mutation in APC, a missense mutation in KRAS. Variants of uncert… (full text at CIViC) PMID 27004155 · Loaiza-Bonilla et al., 2016 · Open in CIViC	civic

KDR R961W1

Regorafenib Anhydrous

Colorectal Adenocarcinoma

Predictive

Supports Sensitivity Response

accepted

EID1191

Case Report of a 84-year-old woman with stage IVb CRC after progression under 5-fluorouracil and bevacizumab. NGS revealed a frameshift mutation in APC, a missense mutation in KRAS. Variants of uncert… (full text at CIViC)

PMID 27004155 · Loaiza-Bonilla et al., 2016 · Open in CIViC

civic

KDR S1100F1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9950 The colon cancer cell line COLO-320 was transfected with VEGFR2 (KDR) S1100F mutation. When injected into immune deficient mice, these cells were capable of causing tumor formation reaching the establ… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR S1100F1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9950

The colon cancer cell line COLO-320 was transfected with VEGFR2 (KDR) S1100F mutation. When injected into immune deficient mice, these cells were capable of causing tumor formation reaching the establ… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic

KDR S925F1
(oncogenic)	Malignant Colorectal NeoplasmCURATED_BROADER	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9955 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) S925F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic

KDR S925F1

(oncogenic)

Malignant Colorectal NeoplasmCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID9955

COLO-320 colon cancer cells transfected with VEGFR2 (KDR) S925F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC)

PMID 29588308 · Toledo et al., 2018 · Open in CIViC

civic