Publication
Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerMalignant Colorectal Neoplasmcivic_curation1.00
- drugAxitinibcivic_curation1.00
- drugCabozantinibcivic_curation1.00
- drugDovitinibcivic_curation1.00
- drugLenvatinibcivic_curation1.00
- geneKDRcivic_curation1.00
- variantKDR R1032Qcivic_curation1.00
Curated evidence
Evidence citing this paper (9)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 29588308
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KDR G800D1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9952COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR G800R1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9953COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G800R caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR G843D1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9954COLO-320 colon cancer cells transfected with VEGFR2 (KDR) G843D caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR L840F1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9951COLO-320 colon cancer cells transfected with VEGFR2 (KDR) L840F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR R1022Q1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9956COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1022Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR R1032Q2 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9957COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1032Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| Axitinib + Cabozantinib + Dovitinib + LenvatinibSubstitutes | Malignant Colorectal NeoplasmCURATED_BROADER | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID9339R1032Q affects the gene's universal kinase catalytic motif. The authors found that injection of mice with COLO-320 cells that harbor this mutation resulted in tumor generation, indicating that this mu… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR S1100F1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9950The colon cancer cell line COLO-320 was transfected with VEGFR2 (KDR) S1100F mutation. When injected into immune deficient mice, these cells were capable of causing tumor formation reaching the establ… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |
| KDR S925F1 | ||||||||
| (oncogenic) | Malignant Colorectal NeoplasmCURATED_BROADER | Oncogenic | D | Supports Oncogenicity | 2 | submitted | EID9955COLO-320 colon cancer cells transfected with VEGFR2 (KDR) S925F caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGFR… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC | civic |