KDR R1032Q

CI-VAR-00003608Explore in graph →CIViC 3350

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm2
KDR R1032Q	(oncogenic)	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9957 COLO-320 colon cancer cells transfected with VEGFR2 (KDR) R1032Q caused tumor formation reaching the established humane endpoint in immune deficient mice, while empty vector and a kinase inactive VEGF… (full text at CIViC) PMID 29588308 · Toledo et al., 2018 · Open in CIViC	civic
KDR R1032Q	Axitinib + Cabozantinib + Dovitinib + LenvatinibSubstitutes	Predictive	D	Supports Sensitivity Response	2	accepted	EID9339 R1032Q affects the gene's universal kinase catalytic motif. The authors found that injection of mice with COLO-320 cells that harbor this mutation resulted in tumor generation, indicating that this mu… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.