Publication
KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerAngiosarcomacivic_curation1.00
- drugSorafenibcivic_curation1.00
- drugSunitinibcivic_curation1.00
- geneKDRcivic_curation1.00
- variantKDR A1065Tcivic_curation1.00
- variantKDR D717Vcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19723655
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| KDR A1065T1 | ||||||||
| Sorafenib + SunitinibSubstitutes | Angiosarcoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1106COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or A1065T-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type c… (full text at CIViC) PMID 19723655 · Antonescu et al., 2009 · Open in CIViC | civic |
| KDR D717V1 | ||||||||
| Sorafenib + SunitinibSubstitutes | Angiosarcoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1107COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or D717V-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type ce… (full text at CIViC) PMID 19723655 · Antonescu et al., 2009 · Open in CIViC | civic |