KDR A1065T

CI-VAR-00000042Explore in graph →NP_002244.1:p.Ala1065ThrNM_002253.2:c.3193G>ACIViC 467 rs56302315

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Angiosarcoma1
KDR A1065T	Sorafenib + SunitinibSubstitutes	Predictive	D	Supports Sensitivity Response	3	accepted	EID1106 COS-7 cells were transiently transfected with expression constructs encoding cDNAs for wild-type or A1065T-mutant KDR. Autophosphorylation was observed on tyrosine of mutant cells, but not wild-type c… (full text at CIViC) PMID 19723655 · Antonescu et al., 2009 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.