Gene

IKZF1

IKAROS family zinc finger 1

Explore in graph →CI-GENE-00005994HGNC:13176 ENSG00000185811 NCBI 10320 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (19)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–19 of 19 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
IKZF1 D186fs (c.556del)1
(predisposing)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Predisposing	B	Supports Pathogenic	5	submitted	EID7003 A germline IKZF1 frameshift variant was identified in a proband with BCR-ABL1 positive B-ALL and a family history with incomplete penetrance that included a deceased uncle with B-ALL who was positive … (full text at CIViC) PMID 29681510 · Churchman et al., 2018 · Open in CIViC	civic
IKZF1 Deletion16
(prognostic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Prognostic	A	Supports Poor Outcome	5	accepted	EID7365 This prospective study reports the prognosis of patients with B-ALL and an IKZF1 deletion and the impact of intensification of treatment in this subgroup. In 50 patients from the MS2003 cohort, the 5-…

Cohorts

Alteration frequency by cohort (112)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved112 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
MSK-IMPACT Clinical Sequencing Cohort (MSK, Nat Med 2017) msk_impact_2017	unmapped	Ssm	193	10,945

Literature

Linked publications (10)

25 per page, newest first.

pubmedPublishedShowing 1–10 of 10 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study.
· J Clin Oncol · 2018 · PMID 30044693 · validated civic_curation pubmed
The impact of IKZF1 deletion on the prognosis of acute lymphoblastic leukemia: an updated meta-analysis.
· Cancer Biomark · 2014 · PMID 25335741 · validated civic_curation pubmed
Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia.
· Leukemia · 2013 · PMID 22699455 · validated civic_curation pubmed
Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia.
· Blood · 2014 · PMID 24740809

CDKN2A Deletion + CDKN2B Deletion + ERG Deletion + IKZF1 Deletion + CRLF2 Fusion + PAX5 DeletionPAX5 CDKN2B ERG IKZF1 CRLF2 CDKN2A1
(prognostic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	5	submitted	EID7786 83 of 991 cases of pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were found to have IKZF1 deletion, previously reported as an independent factor associated with a poor prognosis.… (full text at CIViC) PMID 29498923 · Stanulla et al., 2018 · Open in CIViC	civic

CDKN2A Deletion + CDKN2B Deletion + ERG Deletion + IKZF1 Deletion + CRLF2 Fusion + PAX5 DeletionPAX5 CDKN2B ERG IKZF1 CRLF2 CDKN2A1

(prognostic)

B Lymphoblastic Leukemia/LymphomaCURATED_BROADER

Prognostic

Supports Poor Outcome

submitted

EID7786

83 of 991 cases of pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were found to have IKZF1 deletion, previously reported as an independent factor associated with a poor prognosis.… (full text at CIViC)

PMID 29498923 · Stanulla et al., 2018 · Open in CIViC

civic

IKZF1 Loss-of-function1
(prognostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Prognostic	B	Supports Poor Outcome	4	accepted	EID7383 This study reports on two pediatric cohorts with B-ALL. In the first cohort of 221 high risk, BCR-ABL1-negative pediatric patients, 55.2% of IKZF1 positive patients had a hematologic relapse, 73.4% of… (full text at CIViC) PMID 19129520 · Mullighan et al., 2009 · Open in CIViC	civic

IKZF1 Loss-of-function1

(prognostic)

Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED

Prognostic

Supports Poor Outcome

accepted

EID7383

This study reports on two pediatric cohorts with B-ALL. In the first cohort of 221 high risk, BCR-ABL1-negative pediatric patients, 55.2% of IKZF1 positive patients had a hematologic relapse, 73.4% of… (full text at CIViC)

PMID 19129520 · Mullighan et al., 2009 · Open in CIViC

civic