IKZF1 Loss-of-function

CI-VAR-00002539Explore in graph →CIViC 2744

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Childhood B-cell Acute Lymphoblastic Leukemia1unmapped disease
IKZF1 Loss-of-function	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID7383 This study reports on two pediatric cohorts with B-ALL. In the first cohort of 221 high risk, BCR-ABL1-negative pediatric patients, 55.2% of IKZF1 positive patients had a hematologic relapse, 73.4% of… (full text at CIViC) PMID 19129520 · Mullighan et al., 2009 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.