IKZF1 D186fs (c.556del)

CI-VAR-00000443Explore in graph →NP_001207694.1:p.Asp186fsNM_001220765.2:c.556delCIViC 2579

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Childhood B-cell Acute Lymphoblastic Leukemia1unmapped disease
IKZF1 D186fs (c.556del)	(predisposing)	Predisposing	B	Supports Pathogenic	5	submitted	EID7003 A germline IKZF1 frameshift variant was identified in a proband with BCR-ABL1 positive B-ALL and a family history with incomplete penetrance that included a deceased uncle with B-ALL who was positive … (full text at CIViC) PMID 29681510 · Churchman et al., 2018 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.