Publication
Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerB Lymphoblastic Leukemia/Lymphomacivic_curation1.00
- drugCytarabinecivic_curation1.00
- drugDaunorubicincivic_curation1.00
- drugFludarabinecivic_curation1.00
- drugImatinibcivic_curation1.00
- drugMethotrexatecivic_curation1.00
- geneIKZF1civic_curation1.00
- variantIKZF1 Deletioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 30044693
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| IKZF1 Deletion2 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | A | Supports Poor Outcome | 5 | accepted | EID7365This prospective study reports the prognosis of patients with B-ALL and an IKZF1 deletion and the impact of intensification of treatment in this subgroup. In 50 patients from the MS2003 cohort, the 5-… (full text at CIViC) PMID 30044693 · Yeoh et al., 2018 · Open in CIViC | civic |
| Cytarabine + Daunorubicin + Fludarabine + Imatinib + MethotrexateCombination | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Predictive | B | Supports Sensitivity Response | 4 | accepted | EID7366This prospective study reports on the prognosis of patients with B-ALL and an IKZF1 deletion and the impact of intensification of treatment in this subgroup. In 50 patients from the MS2003 cohort, th… (full text at CIViC) PMID 30044693 · Yeoh et al., 2018 · Open in CIViC | civic |