Publication
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneIKZF1civic_curation1.00
- variantIKZF1 Loss-of-functioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19129520
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| IKZF1 Deletion1 | ||||||||
| (prognostic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Prognostic | B | Supports Poor Outcome | 4 | rejected | EID7391IKZF1 deletions and mutations are associated with adverse outcome (including increased risk of relapse and other adverse events and increased probability of MRD at the end of induction) in patients wi… (full text at CIViC) PMID 19129520 · Mullighan et al., 2009 · Open in CIViC | civic |
| IKZF1 Loss-of-function1 | ||||||||
| (prognostic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID7383This study reports on two pediatric cohorts with B-ALL. In the first cohort of 221 high risk, BCR-ABL1-negative pediatric patients, 55.2% of IKZF1 positive patients had a hematologic relapse, 73.4% of… (full text at CIViC) PMID 19129520 · Mullighan et al., 2009 · Open in CIViC | civic |