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Variants & evidence
12 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| CDK4 Overexpression1 | |||||||
| Palbociclib + RibociclibSubstitutes | Predictive | D | Supports Resistance | 3 | submitted | EID7138Analysis of the antiproliferative effects of pharmacologic CDK4/6 inhibitors provided initial evidence of this notion, as lowest CDK4- expressing Rh28 cells showed the highest sensitivity to both LEE0… (full text at CIViC) PMID 25810375 · Olanich et al., 2015 · Open in CIViC | civic |
| FGFR4 Overexpression1 | |||||||
| Ponatinib | Predictive | D | Supports Sensitivity Response | 3 | submitted | EID7137Indeed, cell lines expressing the highest levels of FGFR4 (above a relative level of six) were the most sensitive to ponatinib (Figure 1C, p = 0.0344). These results, therefore, suggest that increased… (full text at CIViC) PMID 24124571 · Li et al., 2013 · Open in CIViC | civic |
| ALK Overexpression + MET OverexpressionMETALK1 | |||||||
| Crizotinib | Predictive | D | Supports Sensitivity Response | 2 | submitted | EID7136Since significant ALK and MET expression was only detected in ARMS samples, the effect of crizotinib, an ATP competitive, MET and ALK inhibitor, was evaluated on the growth of RH4 and RH30 ARMS cell l… (full text at CIViC) PMID 26445453 · Megiorni et al., 2015 · Open in CIViC | civic |
| FOXO1 Fusion5 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID7009In a cohort of 171 pediatric rhabdomyosarcoma patients, the PAX3::FOXO1 fusion transcript was detected in 55% of patients with centrally reviewed ARMS. Critically, this fusion, along with the related … (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID11684In this study, a total of 147 rhabdomyosarcomas/normal pairs were analyzed, 44 by whole genome sequencing and 103 tumors by whole exome sequencing. 50 cases classified as alveolar rhabdomyosarcoma his… (full text at CIViC) PMID 24436047 · Shern et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID11687This study summarizes the evolution of the classification of rhabdomyosarcomas which now includes embryonal, alveolar, spindle cell/sclerosing and pleomorphic rhabdomyosarcoma. Genetically, alveolar r… | |
| FOXO1 Fusion4 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID7010In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID11685In this study, a total of 147 rhabdomyosarcomas/normal pairs were analyzed, 44 by whole genome sequencing and 103 tumors by whole exome sequencing. 50 cases classified as alveolar rhabdomyosarcoma his… (full text at CIViC) PMID 24436047 · Shern et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID11686This study summarizes the evolution of the classification of rhabdomyosarcomas which now includes embryonal, alveolar, spindle cell/sclerosing and pleomorphic rhabdomyosarcoma. Genetically, alveolar r… | |
Data updated 22 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
PMID 34958505 · Agaram, 2022 · Open in CIViC
| civic |
| (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID8885In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC | civic |
| BET Inhibitor | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID70115 PAX3-FOXO1 fusion positive rhabdomyosarcoma cell lines exhibited greater sensitivity to BET bromodomain inhibitors than fusion negative lines and introduction of the PAX3-FOXO1 fusion to fibroblasts… (full text at CIViC) PMID 28446439 · Gryder et al., 2017 · Open in CIViC | civic |
PMID 34958505 · Agaram, 2022 · Open in CIViC
| civic |
| (prognostic) | Prognostic | B | Supports Better Outcome | 3 | accepted | EID8886In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC | civic |