FOXO1 mutation

CI-VAR-00004997Explore in graph →CIViC 4758

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Burkitt Lymphoma1
FOXO1 mutation	(oncogenic)	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11819 FOXO1 mutations are associated with multiple B-cell lymphomas including BL as described in the referenced study PMID 30617194 · Grande et al., 2019 · Open in CIViC	civic
Diffuse Large B-Cell Lymphoma1
FOXO1 mutation	(oncogenic)	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11934 This study used a combination of RNA-seq, whole genome and targeted sequencing to identify recurrently mutated genes in follicular and diffuse large B-cell lymphoma. They reported 30 genes that had si… (full text at CIViC) PMID 21796119 · Morin et al., 2011 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.