FOXO1 Fusion

CI-VAR-00001237Explore in graph →CIViC 2582

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Alveolar Rhabdomyosarcoma5
PAX3::FOXO1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID7009 In a cohort of 171 pediatric rhabdomyosarcoma patients, the PAX3::FOXO1 fusion transcript was detected in 55% of patients with centrally reviewed ARMS. Critically, this fusion, along with the related … (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC	civic
PAX3::FOXO1 Fusion	(prognostic)	Prognostic	B	Supports Poor Outcome	3	accepted	EID8885 In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.