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Variants & evidence
27 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| ARID1A Q185*1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11813Reported as significantly mutated in BL per the cited study. An arbitrarily selected variant from the study is included here. PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| BCL7A mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11816Mutations in this gene have been described in several studies including the one referenced here. PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| BMP7 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 2 | submitted | EID11837Observed mutated in BL in more than one genomic data set PMID 31558468 · Panea et al., 2019 · Open in CIViC | civic |
| CCND3 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11814Many mutations in CCND3 have been described in the cited study and other studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| CDKN2A Mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11815Mutations have been described in several studies including the one cited. PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| CHD8 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11817Mutations in this gene have been described as a feature of some BLs as per this study PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| DDX3X D347G1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11812DDX3X mutations are one of the most common somatic alterations in BL. This is just an arbitrarily chosen example of a mutation observed in the cited study. PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| EIF4A1 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11838Recurrence of mutations confirmed by multiple studies PMID 31558468 · Panea et al., 2019 · Open in CIViC | civic |
| FBXO11 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | civic | |
| FOXO1 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11819FOXO1 mutations are associated with multiple B-cell lymphomas including BL as described in the referenced study PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| GNA13 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11821Mutations in this gene have been described in several genome-wide studies of B-cell lymphomas including this one PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| GNAI2 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11839Mutated at high frequency in both DLBCL and BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| HNRNPU mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11840Recurrence of mutations now confirmed by multiple studies PMID 31558468 · Panea et al., 2019 · Open in CIViC | civic |
| ID3 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 4 | submitted | EID11841ID3 mutations have been firmly established as a distinguishing genetic feature of BL and are one of the defining mutations in the new BL genetic subgrouping system proposed by Thomas et al PMID 23143595 · Richter et al., 2012 · Open in CIViC | civic |
| KMT2D mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11835More common in DLBCL but also mutated in BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| P2RY8 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11834Mutations in this gene are common in BL according to several studies PMID 25274307 · Muppidi et al., 2014 · Open in CIViC | civic |
| PCBP1 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11833Described in several BL studies after this one PMID 26173642 · Wagener et al., 2015 · Open in CIViC | civic |
| PTEN Mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | civic | |
| RFX7 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11831Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| RHOA MUTATION1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11830Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| SIN3A mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11829Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| SMARCA4 Mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11828Described in multiple genome-wide studies PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| TCF3 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11827First described in Schmitz but has been observed in multiple other BL studies PMID 22885699 · Schmitz et al., 2012 · Open in CIViC | civic |
| TFAP4 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11826Mutations in this gene have been described in several genome-wide studies PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| TP53 Mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 4 | submitted | civic | |
| USP7 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11824Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC | civic |
| WNK1 mutation1 | |||||||
| (oncogenic) | Oncogenic | E | Supports Oncogenicity | 3 | submitted | EID11823Described in recent genome-wide study of BL and DLBCL PMID 36201743 · Thomas et al., 2023 · Open in CIViC | civic |
Data updated 15 minutes agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.