Gene

FLI1

Fli-1 proto-oncogene, ETS transcription factor

Explore in graph →CI-GENE-00002028HGNC:3749 ENSG00000151702 NCBI 2313 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (10)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–10 of 10 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FLI1 e7::e61
(prognostic)	Ewing Sarcoma	Prognostic	B	Supports Better Outcome	4	accepted	EID431 In patients with Ewing's sarcoma, those with type 1 EWS-FLI1 fusions had longer overall survival than those with other types of EWS-FLI1 fusions.

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Glioblastoma (TCGA, Nature 2008) gbm_tcga_pub	Diffuse Glioma	Ssm	2	91	2.2%

Literature

Linked publications (7)

25 per page, newest first.

pubmedPublishedShowing 1–7 of 7 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Integrated multimodal genetic testing of Ewing sarcoma--a single-institution experience.
· Hum Pathol · 2013 · PMID 23706910 · validated civic_curation pubmed
EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.
· J Clin Oncol · 1998 · PMID 9552022 · validated civic_curation pubmed
Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12).
· Cancer Genet Cytogenet · 1988 · PMID 3163261 · validated civic_curation pubmed
Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors.
· Mod Pathol · 2006 · PMID 16258512 · validated

FLI1 Fusion8
(diagnostic)	Ewing Sarcoma	Diagnostic	B	Supports Positive	5	accepted	EID478 t(11;22) rearrangements of EWSR1-FLI1 are diagnostic of ewing sarcoma, and are observed in 90% of cytogenetic samples. PMID 23706910 · Warren et al., 2013 · Open in CIViC	civic
〃	Bone Ewing SarcomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID1752 A total of 85 unrelated cases of Ewing's sarcoma were examined and 83% were found to harbor the t(11;22)(q24;q12) chromosomal abnormality knwon to result in the EWSR1::FLI1 fusion. PMID 3163261 · Turc-Carel et al., 1988 · Open in CIViC	civic
〃	Bone Ewing SarcomaALIAS	Diagnostic	B	Supports Positive	3	accepted	EID1754 An evaluation of alternative strategies for detection of EWS-FLI (FISH break apart, FISH fusion, and RT-PCR). Of the 22 informative EWS/PNETs, 20 cases (91%) were positive by FISH break apart, FISH f… (full text at CIViC) PMID 16258512 · Bridge et al., 2006 · Open in CIViC	civic
〃	Ewing Sarcoma	Diagnostic	B	Supports Positive	3	accepted	EID10337 Molecular analysis of 30 Ewing tumors (designated as Ewing's sarcomas and primitive neuroectodermal tumors (PNET) in this 1994 paper) from patients with well-documented clinical course was performed. … (full text at CIViC) PMID 7524604 · Zoubek et al., 1994 · Open in CIViC	civic
〃	Bone Ewing SarcomaALIAS	Diagnostic	B	Supports Positive	2	accepted	EID1753 The authors propose RT-PCR as a diagnostic test for Ewing sarcoma using FFPE materials. Starting with 40 cases, intact RNA could be isolated from 6, and of these the EWSR1-FLI1 fusion was detected in… (full text at CIViC) PMID 9741544 · Park et al., 1998 · Open in CIViC	civic
Elimusertib	Ewing Sarcoma	Predictive	D	Supports Sensitivity Response	2	submitted	EID12541 In preclinical models of FET fusion–positive cancers, suppression of ATM signaling by the EWSR1-FLI1 oncoprotein created dependence on ATR-mediated repair. The ATR inhibitor elimusertib showed potent … (full text at CIViC) PMID 37205599 · Menon et al., 2025 · Open in CIViC	civic
HCI-2509	Ewing Sarcoma	Predictive	D	Supports Sensitivity Response	2	accepted	EID12516 Preclinical studies demonstrated that the LSD1 inhibitor HCI-2509 reduced proliferation and induced apoptosis in five EWSR1-FLI1 fusion-positive Ewing sarcoma cell lines (A673, TC32, TC71, SK-N-MC, CH… (full text at CIViC) PMID 24963049 · Sankar et al., 2014 · Open in CIViC	civic
Trabectedin	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	2	submitted	EID12543 In a randomized phase II trial (n = 73) of patients with advanced translocation-related sarcoma, trabectedin (1.2 mg/m² q3w) significantly improved progression-free survival compared with best support… (full text at CIViC) PMID 25795406 · Kawai et al., 2015 · Open in CIViC	civic

FLI1 Fusion8

(diagnostic)

Ewing Sarcoma

Diagnostic

Supports Positive

accepted

EID478

t(11;22) rearrangements of EWSR1-FLI1 are diagnostic of ewing sarcoma, and are observed in 90% of cytogenetic samples.

PMID 23706910 · Warren et al., 2013 · Open in CIViC

civic

〃

Bone Ewing SarcomaALIAS

Diagnostic

Supports Positive

accepted

EID1752

A total of 85 unrelated cases of Ewing's sarcoma were examined and 83% were found to harbor the t(11;22)(q24;q12) chromosomal abnormality knwon to result in the EWSR1::FLI1 fusion.

PMID 3163261 · Turc-Carel et al., 1988 · Open in CIViC

civic

〃

Bone Ewing SarcomaALIAS

Diagnostic

Supports Positive

accepted

EID1754

An evaluation of alternative strategies for detection of EWS-FLI (FISH break apart, FISH fusion, and RT-PCR). Of the 22 informative EWS/PNETs, 20 cases (91%) were positive by FISH break apart, FISH f… (full text at CIViC)

PMID 16258512 · Bridge et al., 2006 · Open in CIViC

civic

〃

Ewing Sarcoma

Diagnostic

Supports Positive

accepted

EID10337

Molecular analysis of 30 Ewing tumors (designated as Ewing's sarcomas and primitive neuroectodermal tumors (PNET) in this 1994 paper) from patients with well-documented clinical course was performed. … (full text at CIViC)

PMID 7524604 · Zoubek et al., 1994 · Open in CIViC

civic

〃

Bone Ewing SarcomaALIAS

Diagnostic

Supports Positive

accepted

EID1753

The authors propose RT-PCR as a diagnostic test for Ewing sarcoma using FFPE materials. Starting with 40 cases, intact RNA could be isolated from 6, and of these the EWSR1-FLI1 fusion was detected in… (full text at CIViC)

PMID 9741544 · Park et al., 1998 · Open in CIViC

civic

Elimusertib

Ewing Sarcoma

Predictive

Supports Sensitivity Response

submitted

EID12541

In preclinical models of FET fusion–positive cancers, suppression of ATM signaling by the EWSR1-FLI1 oncoprotein created dependence on ATR-mediated repair. The ATR inhibitor elimusertib showed potent … (full text at CIViC)

PMID 37205599 · Menon et al., 2025 · Open in CIViC

civic

HCI-2509

Ewing Sarcoma

Predictive

Supports Sensitivity Response

accepted

EID12516

Preclinical studies demonstrated that the LSD1 inhibitor HCI-2509 reduced proliferation and induced apoptosis in five EWSR1-FLI1 fusion-positive Ewing sarcoma cell lines (A673, TC32, TC71, SK-N-MC, CH… (full text at CIViC)

PMID 24963049 · Sankar et al., 2014 · Open in CIViC

civic

Trabectedin

Malignant NeoplasmALIAS

Predictive

Supports Sensitivity Response

submitted

EID12543

In a randomized phase II trial (n = 73) of patients with advanced translocation-related sarcoma, trabectedin (1.2 mg/m² q3w) significantly improved progression-free survival compared with best support… (full text at CIViC)

PMID 25795406 · Kawai et al., 2015 · Open in CIViC

civic

ATF1 Fusion + FLI1 Fusion + WT1 FusionFLI1 WT1 ATF11
Trabectedin	Sarcoma	Predictive	B	Supports Sensitivity Response	2	submitted	EID12544 In a pooled analysis of two phase II studies (n = 66) of advanced translocation-related sarcoma, trabectedin (1.2 mg/m² q3w) produced median PFS 5.6 months (95% CI 4.1–7.3) and median OS 17.5 months (… (full text at CIViC) PMID 28526720 · Takahashi et al., 2017 · Open in CIViC	civic

ATF1 Fusion + FLI1 Fusion + WT1 FusionFLI1 WT1 ATF11

Trabectedin

Sarcoma

Predictive

Supports Sensitivity Response

submitted

EID12544

In a pooled analysis of two phase II studies (n = 66) of advanced translocation-related sarcoma, trabectedin (1.2 mg/m² q3w) produced median PFS 5.6 months (95% CI 4.1–7.3) and median OS 17.5 months (… (full text at CIViC)

PMID 28526720 · Takahashi et al., 2017 · Open in CIViC

civic