Publication
Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.
Authors not recorded
Clin Cancer Res2014PMID 24963049PMC4155010stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
No abstract stored. Read on PubMed
Linked entities
Linked entities (4)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 4
- cancerEwing Sarcomacivic_curation1.00
- drugHCI-2509civic_curation1.00
- geneFLI1civic_curation1.00
- variantFLI1 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24963049
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FLI1 Fusion1 | ||||||||
| HCI-2509 | Ewing Sarcoma | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID12516Preclinical studies demonstrated that the LSD1 inhibitor HCI-2509 reduced proliferation and induced apoptosis in five EWSR1-FLI1 fusion-positive Ewing sarcoma cell lines (A673, TC32, TC71, SK-N-MC, CH… (full text at CIViC) PMID 24963049 · Sankar et al., 2014 · Open in CIViC | civic |