Variant · Fusion
FLI1 Fusion
CI-VAR-00001197Explore in graph →CIViC 706
Curated evidence
Evidence by cancer (9 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 3163261
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Bone Ewing Sarcoma3 | ||||||||
| EWSR1::FLI1 Fusion | (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID1752A total of 85 unrelated cases of Ewing's sarcoma were examined and 83% were found to harbor the t(11;22)(q24;q12) chromosomal abnormality knwon to result in the EWSR1::FLI1 fusion. PMID 3163261 · Turc-Carel et al., 1988 · Open in CIViC | civic |
| EWSR1::FLI1 Fusion | (diagnostic) | Diagnostic | B | Supports Positive | 2 | accepted | EID1753The authors propose RT-PCR as a diagnostic test for Ewing sarcoma using FFPE materials. Starting with 40 cases, intact RNA could be isolated from 6, and of these the EWSR1-FLI1 fusion was detected in… (full text at CIViC) PMID 9741544 · Park et al., 1998 · Open in CIViC | civic |
| EWSR1::FLI1 Fusion | ||||||||
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available