ATF1 — gene · CancerIndex

Curated evidence

Clinical evidence (7)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ATF1 Fusion5
(diagnostic)	Clear Cell Sarcoma of Soft TissueALIAS	Diagnostic	B	Supports Positive	4	accepted	EID8265 In this study, the authors analyzed 17 clear cell sarcomas from 16 patients, along with 2 positive control cell lines and 2 melanomas as negative controls, to investigate the prevalence and types of E… (full text at CIViC) PMID 19561568 · Wang et al., 2009 · Open in CIViC	civic
〃	Clear Cell Sarcoma of Soft TissueALIAS	Diagnostic	B	Supports Positive	3	accepted	EID12829 In this 2018 study by Keiko Segawa et al., the authors analyzed 22 tumors, including 16 clear cell sarcomas of soft tissue (CCSST) and 6 clear cell sarcoma–like gastrointestinal tumors (CCSLGT), to ch… (full text at CIViC)

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Miscellaneous Neuroepithelial Tumor (TCGA GDC, 2025) mnet_tcga_gdc	Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin	Ssm	1

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts).
· Mod Pathol · 2009 · PMID 19561568 · validated civic_curation pubmed
Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor.
· Diagn Pathol · 2018 · PMID 30219084 · validated civic_curation pubmed
Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases.
· J Mol Diagn · 2002 · PMID 11826187 · validated civic_curation pubmed