Thyroid Gland Neoplasm — Genomics

Thyroid Gland Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

6 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Comprehensive genomic characterization of radiation-related papillary thyroid cancer in the Ukraine REBC-THYRREBC

394 cases with simple somatic mutation data · 449 cases total · Data Release 46.0 · mapped to Thyroid Gland Papillary Carcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Papillary Thyroid Cancer (TCGA GDC, 2025) thpa_tcga_gdcTCGA GDC

496 cases with simple somatic mutation data · 515 cases total · 2026-01-14 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	293	496	59.1%	cbioportal
2	NRAS	Ssm	39	496	7.9%	cbioportal
3	TG	Ssm	19	496	3.8%	cbioportal
4	HRAS	Ssm	17	496	3.4%	cbioportal
5	TTN	Ssm	16	496	3.2%	cbioportal
9	SPTA1	Ssm	7	496	1.4%	cbioportal
7	KMT2A	Ssm	7	496	1.4%	cbioportal
6	EIF1AX	Ssm	7	496	1.4%	cbioportal
10	ZFHX3	Ssm	7	496	1.4%	cbioportal
8	MUC16	Ssm	7	496	1.4%	cbioportal
12	USP9X	Ssm	6	496	1.2%	cbioportal
11	BDP1	Ssm	6	496	1.2%	cbioportal
19	RYR1	Ssm	5	496	1%	cbioportal
17	PDZD2	Ssm	5	496	1%	cbioportal
16	PCDH11X	Ssm	5	496	1%	cbioportal
15	GBF1	Ssm	5	496	1%	cbioportal
14	ATM	Ssm	5	496	1%	cbioportal
13	AKT1	Ssm	5	496	1%	cbioportal
18	PTPRZ1	Ssm	5	496	1%	cbioportal
30	JMJD1C	Ssm	4	496	0.8%	cbioportal
20	ABCB11	Ssm	4	496	0.8%	cbioportal
21	ARFGEF2	Ssm	4	496	0.8%	cbioportal
22	ARID2	Ssm	4	496	0.8%	cbioportal
23	BPTF	Ssm	4	496	0.8%	cbioportal
24	BSN	Ssm	4	496	0.8%	cbioportal
25	CHEK2	Ssm	4	496	0.8%	cbioportal
26	CSMD2	Ssm	4	496	0.8%	cbioportal
27	GRIN2B	Ssm	4	496	0.8%	cbioportal
28	HMCN1	Ssm	4	496	0.8%	cbioportal
29	ITPR2	Ssm	4	496	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Papillary Thyroid Carcinoma (TCGA, Cell 2014) thca_tcga_pubTCGA

496 cases with simple somatic mutation data · 496 cases total · 2026-01-13 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	240	496	48.4%	cbioportal
2	TERT	Ssm	37	496	7.5%	cbioportal
3	NRAS	Ssm	34	496	6.9%	cbioportal
4	HRAS	Ssm	14	496	2.8%	cbioportal
5	TTN	Ssm	13	496	2.6%	cbioportal
6	TG	Ssm	11	496	2.2%	cbioportal
7	MUC16	Ssm	10	496	2%	cbioportal
8	DNAH9	Ssm	9	496	1.8%	cbioportal
10	ZFHX3	Ssm	7	496	1.4%	cbioportal
9	KMT2A	Ssm	7	496	1.4%	cbioportal
11	EIF1AX	Ssm	6	496	1.2%	cbioportal
12	SPTA1	Ssm	6	496	1.2%	cbioportal
22	LRP1	Ssm	5	496	1%	cbioportal
21	ITPR2	Ssm	5	496	1%	cbioportal
20	COL5A3	Ssm	5	496	1%	cbioportal
19	CHEK2	Ssm	5	496	1%	cbioportal
18	CACNA1E	Ssm	5	496	1%	cbioportal
17	BDP1	Ssm	5	496	1%	cbioportal
16	ATM	Ssm	5	496	1%	cbioportal
15	ARID1B	Ssm	5	496	1%	cbioportal
14	APOB	Ssm	5	496	1%	cbioportal
13	ADGRV1	Ssm	5	496	1%	cbioportal
26	PPM1D	Ssm	5	496	1%	cbioportal
27	PRKDC	Ssm	5	496	1%	cbioportal
25	OTUD4	Ssm	5	496	1%	cbioportal
24	OBSCN	Ssm	5	496	1%	cbioportal
23	MUC5B	Ssm	5	496	1%	cbioportal
30	CDH8	Ssm	4	496	0.8%	cbioportal
28	ARFGEF2	Ssm	4	496	0.8%	cbioportal
29	CD163	Ssm	4	496	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Thyroid Carcinoma TCGA-THCATCGA

507 cases with simple somatic mutation data · 507 cases total · Data Release 46.0 · mapped to Thyroid Gland Carcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	302	507	59.6%	gdc
3	THOC5	Ssm	71	507	14%	gdc
2	TCN2	Ssm	71	507	14%	gdc
6	EIF4ENIF1	Ssm	70	507	13.8%	gdc
15	SF3A1	Ssm	70	507	13.8%	gdc
14	DEPDC5	Ssm	70	507	13.8%	gdc
13	CELSR1	Ssm	70	507	13.8%	gdc
12	RFPL1	Ssm	70	507	13.8%	gdc
11	TNRC6B	Ssm	70	507	13.8%	gdc
10	PLA2G3	Ssm	70	507	13.8%	gdc
9	PISD	Ssm	70	507	13.8%	gdc
8	SEC14L4	Ssm	70	507	13.8%	gdc
7	SEC14L2	Ssm	70	507	13.8%	gdc
5	ZNRF3	Ssm	70	507	13.8%	gdc
4	SFI1	Ssm	70	507	13.8%	gdc
17	PATZ1	Ssm	69	507	13.6%	gdc
16	MORC2	Ssm	69	507	13.6%	gdc
20	SLC35E4	Ssm	69	507	13.6%	gdc
19	NEFH	Ssm	69	507	13.6%	gdc
30	PES1	Ssm	69	507	13.6%	gdc
29	DRG1	Ssm	69	507	13.6%	gdc
18	SLC5A1	Ssm	69	507	13.6%	gdc
28	CCDC157	Ssm	69	507	13.6%	gdc
27	MPPED1	Ssm	69	507	13.6%	gdc
26	LIMK2	Ssm	69	507	13.6%	gdc
25	SMTN	Ssm	69	507	13.6%	gdc
24	FBXO7	Ssm	69	507	13.6%	gdc
23	PIK3IP1	Ssm	69	507	13.6%	gdc
22	EWSR1	Ssm	69	507	13.6%	gdc
21	TUG1	Ssm	69	507	13.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Thyroid Carcinoma (TCGA, Firehose Legacy) thca_tcgaTCGA

405 cases with simple somatic mutation data · 516 cases total · 2026-01-13 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	242	405	59.8%	cbioportal
2	NRAS	Ssm	34	405	8.4%	cbioportal
3	HRAS	Ssm	14	405	3.5%	cbioportal
4	TTN	Ssm	13	405	3.2%	cbioportal
5	TG	Ssm	11	405	2.7%	cbioportal
6	MUC16	Ssm	10	405	2.5%	cbioportal
7	DNAH9	Ssm	9	405	2.2%	cbioportal
9	ZFHX3	Ssm	7	405	1.7%	cbioportal
8	KMT2A	Ssm	7	405	1.7%	cbioportal
11	SPTA1	Ssm	6	405	1.5%	cbioportal
10	EIF1AX	Ssm	6	405	1.5%	cbioportal
23	OBSCN	Ssm	5	405	1.2%	cbioportal
22	MUC5B	Ssm	5	405	1.2%	cbioportal
21	LRP1	Ssm	5	405	1.2%	cbioportal
20	ITPR2	Ssm	5	405	1.2%	cbioportal
19	COL5A3	Ssm	5	405	1.2%	cbioportal
18	CHEK2	Ssm	5	405	1.2%	cbioportal
17	CACNA1E	Ssm	5	405	1.2%	cbioportal
16	BDP1	Ssm	5	405	1.2%	cbioportal
15	ATM	Ssm	5	405	1.2%	cbioportal
14	ARID1B	Ssm	5	405	1.2%	cbioportal
13	APOB	Ssm	5	405	1.2%	cbioportal
12	ADGRV1	Ssm	5	405	1.2%	cbioportal
28	PRKDC	Ssm	5	405	1.2%	cbioportal
27	PPM1D	Ssm	5	405	1.2%	cbioportal
26	PCDHGC5	Ssm	5	405	1.2%	cbioportal
25	PCDHAC2	Ssm	5	405	1.2%	cbioportal
24	OTUD4	Ssm	5	405	1.2%	cbioportal
29	ARFGEF2	Ssm	4	405	1%	cbioportal
30	CD163	Ssm	4	405	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Thyroid Carcinoma (TCGA, PanCancer Atlas) thca_tcga_pan_can_atlas_2018TCGA

490 cases with simple somatic mutation data · 500 cases total · 2026-06-04 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	287	490	58.6%	cbioportal
2	NRAS	Ssm	39	490	8%	cbioportal
3	TTN	Ssm	21	490	4.3%	cbioportal
4	TG	Ssm	19	490	3.9%	cbioportal
5	HRAS	Ssm	16	490	3.3%	cbioportal
6	MUC16	Ssm	13	490	2.7%	cbioportal
8	ZFHX3	Ssm	10	490	2%	cbioportal
7	DNAH9	Ssm	10	490	2%	cbioportal
9	SPTA1	Ssm	8	490	1.6%	cbioportal
16	PLEC	Ssm	7	490	1.4%	cbioportal
14	KMT2A	Ssm	7	490	1.4%	cbioportal
13	ITPR2	Ssm	7	490	1.4%	cbioportal
12	EIF1AX	Ssm	7	490	1.4%	cbioportal
15	MACF1	Ssm	7	490	1.4%	cbioportal
11	DNAH2	Ssm	7	490	1.4%	cbioportal
10	COL5A3	Ssm	7	490	1.4%	cbioportal
17	RYR1	Ssm	7	490	1.4%	cbioportal
18	ADGRV1	Ssm	6	490	1.2%	cbioportal
24	PIK3R5	Ssm	6	490	1.2%	cbioportal
23	MUC5B	Ssm	6	490	1.2%	cbioportal
22	KMT2C	Ssm	6	490	1.2%	cbioportal
21	HMCN1	Ssm	6	490	1.2%	cbioportal
20	FAT3	Ssm	6	490	1.2%	cbioportal
19	ATM	Ssm	6	490	1.2%	cbioportal
30	CSMD1	Ssm	5	490	1%	cbioportal
25	AKT1	Ssm	5	490	1%	cbioportal
26	ALPK3	Ssm	5	490	1%	cbioportal
27	BDP1	Ssm	5	490	1%	cbioportal
28	BPTF	Ssm	5	490	1%	cbioportal
29	COL7A1	Ssm	5	490	1%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

1	OR11H12	Ssm	104	394	26.4%	gdc
2	SMIM11B	Ssm	99	394	25.1%	gdc
3	KCNE1B	Ssm	99	394	25.1%	gdc
4	SMIM34B	Ssm	99	394	25.1%	gdc
5	FAM243B	Ssm	99	394	25.1%	gdc
6	OR11H1	Ssm	98	394	24.9%	gdc
7	POTEH	Ssm	96	394	24.4%	gdc
8	CNTNAP3C	Ssm	89	394	22.6%	gdc
9	SPATA31A7	Ssm	89	394	22.6%	gdc
10	SPATA31A5	Ssm	88	394	22.3%	gdc
11	FOXD4L5	Ssm	87	394	22.1%	gdc
12	AL391987.1	Ssm	85	394	21.6%	gdc
13	ANKRD20A4P	Ssm	85	394	21.6%	gdc
14	AL391987.2	Ssm	85	394	21.6%	gdc
15	POTEM	Ssm	84	394	21.3%	gdc
16	FOXD4L4	Ssm	84	394	21.3%	gdc
17	CBWD5	Ssm	84	394	21.3%	gdc
18	ANKRD20A3P	Ssm	79	394	20.1%	gdc
19	ZNF658	Ssm	77	394	19.5%	gdc
20	SPATA31A3	Ssm	76	394	19.3%	gdc
21	AL627230.3	Ssm	72	394	18.3%	gdc
22	AL627230.1	Ssm	72	394	18.3%	gdc
23	POTEG	Ssm	70	394	17.8%	gdc
24	TPTE	Ssm	68	394	17.3%	gdc
25	CBWD3	Ssm	67	394	17%	gdc
26	POTEB3	Ssm	67	394	17%	gdc
27	AC135068.1	Ssm	67	394	17%	gdc
28	FAM86B2	Ssm	67	394	17%	gdc
29	AC135068.4	Ssm	67	394	17%	gdc
30	POTEB	Ssm	67	394	17%	gdc