Mesothelial Neoplasm — Genomics · CancerIndex

Mesothelial Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

6 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Mesothelioma TCGA-MESOTCGA

87 cases with simple somatic mutation data · 87 cases total · Data Release 46.0 · mapped to Malignant Mesothelioma CURATED_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ACO2	Ssm	68	87	78.2%	gdc
4	ELFN2	Ssm	68	87	78.2%	gdc
3	EP300	Ssm	68	87	78.2%	gdc
2	WNT7B	Ssm	68	87	78.2%	gdc
8	RANGAP1	Ssm	67	87	77%	gdc
9	SH3BP1	Ssm	67	87	77%	gdc
10	TTC38	Ssm	67	87	77%	gdc
11	TPTEP2-CSNK1E	Ssm

Data updated 22 days agoSource updated Data Release 46.0

Mesothelioma (TCGA, Firehose Legacy) meso_tcgaTCGA

87 cases with simple somatic mutation data · 87 cases total · 2026-01-16 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NF2	Ssm	19	87

Mesothelioma (TCGA, PanCancer Atlas) meso_tcga_pan_can_atlas_2018TCGA

86 cases with simple somatic mutation data · 87 cases total · 2026-06-04 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1

Pleural Mesothelioma (MSK, Clin Cancer Res 2024) plmeso_msk_2024MSK

14 cases with simple somatic mutation data · 14 cases total · 2026-01-13 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	SETDB1

Pleural Mesothelioma (NYU, Cancer Res 2015) plmeso_nyu_2015NYU

22 cases with simple somatic mutation data · 22 cases total · 2026-01-13 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BAP1

Pleural Mesothelioma (TCGA GDC, 2025) plmeso_tcga_gdcTCGA GDC

78 cases with simple somatic mutation data · 87 cases total · 2026-01-13 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BAP1	Ssm	22

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.