Malignant Mixed Neoplasm — Genomics

Malignant Mixed Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

9 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

High-Risk Wilms Tumor TARGET-WTTARGET

631 cases with simple somatic mutation data · 652 cases total · Data Release 46.0 · mapped to Wilms Tumor CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Molecular Profiling to Predict Response to Treatment - Wilms Tumor MP2PRT-WTMP2PRT

51 cases with simple somatic mutation data · 52 cases total · Data Release 46.0 · mapped to Wilms Tumor ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
6	CLEC9A	Ssm	22	51	43.1%	gdc
12	LCE1F	Ssm	22	51	43.1%	gdc
13	PSMB4	Ssm	22	51	43.1%	gdc
14	CHD1L	Ssm	22	51	43.1%	gdc
15	VPS45	Ssm	22	51	43.1%	gdc
16	FLG	Ssm	22	51	43.1%	gdc
17	SELENBP1	Ssm	22	51	43.1%	gdc
18	POGZ	Ssm	22	51	43.1%	gdc
19	LCE3C	Ssm	22	51	43.1%	gdc
20	LCE3B	Ssm	22	51	43.1%	gdc
21	PRPF3	Ssm	22	51	43.1%	gdc
22	CA14	Ssm	22	51	43.1%	gdc
23	H3C13	Ssm	22	51	43.1%	gdc
24	RFX5	Ssm	22	51	43.1%	gdc
25	TCHHL1	Ssm	22	51	43.1%	gdc
26	ACP6	Ssm	22	51	43.1%	gdc
27	CLEC1A	Ssm	22	51	43.1%	gdc
28	LCE4A	Ssm	22	51	43.1%	gdc
29	CLEC12B	Ssm	22	51	43.1%	gdc
30	MRPL9	Ssm	22	51	43.1%	gdc
11	NBPF12	Ssm	22	51	43.1%	gdc
10	ECM1	Ssm	22	51	43.1%	gdc
9	THEM5	Ssm	22	51	43.1%	gdc
8	TUFT1	Ssm	22	51	43.1%	gdc
7	MCL1	Ssm	22	51	43.1%	gdc
5	LINGO4	Ssm	22	51	43.1%	gdc
4	H2BC18	Ssm	22	51	43.1%	gdc
1	H2AC20	Ssm	22	51	43.1%	gdc
3	TMEM52B	Ssm	22	51	43.1%	gdc
2	MTRNR2L6	Ssm	22	51	43.1%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Pediatric Wilms' Tumor (TARGET, 2018) wt_target_2018_pubTARGET

657 cases with simple somatic mutation data · 657 cases total · 2026-01-16 · mapped to Wilms Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	15	657	2.3%	cbioportal
2	CTNNB1	Ssm	7	657	1.1%	cbioportal
3	HLA-DQB1	Ssm	7	657	1.1%	cbioportal
4	CDK11A	Ssm	6	657	0.9%	cbioportal
5	DROSHA	Ssm	6	657	0.9%	cbioportal
6	ADCK5	Ssm	4	657	0.6%	cbioportal
7	MAP3K4	Ssm	4	657	0.6%	cbioportal
8	SIX1	Ssm	4	657	0.6%	cbioportal
9	TMPRSS13	Ssm	4	657	0.6%	cbioportal
10	WT1	Ssm	4	657	0.6%	cbioportal
12	AGRN	Ssm	3	657	0.5%	cbioportal
17	ZNF880	Ssm	3	657	0.5%	cbioportal
16	ZNF595	Ssm	3	657	0.5%	cbioportal
15	MADCAM1	Ssm	3	657	0.5%	cbioportal
14	HYDIN	Ssm	3	657	0.5%	cbioportal
13	DGCR8	Ssm	3	657	0.5%	cbioportal
11	ACTB	Ssm	3	657	0.5%	cbioportal
23	CCDC74B	Ssm	2	657	0.3%	cbioportal
24	CDC42EP1	Ssm	2	657	0.3%	cbioportal
25	CHD4	Ssm	2	657	0.3%	cbioportal
26	CSMD2	Ssm	2	657	0.3%	cbioportal
27	DCP1A	Ssm	2	657	0.3%	cbioportal
28	EGFLAM	Ssm	2	657	0.3%	cbioportal
29	ETNK2	Ssm	2	657	0.3%	cbioportal
30	FAM50A	Ssm	2	657	0.3%	cbioportal
20	ATN1	Ssm	2	657	0.3%	cbioportal
21	ATR	Ssm	2	657	0.3%	cbioportal
22	BCOR	Ssm	2	657	0.3%	cbioportal
18	AK9	Ssm	2	657	0.3%	cbioportal
19	ARID2	Ssm	2	657	0.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Carcinosarcoma TCGA-UCSTCGA

57 cases with simple somatic mutation data · 57 cases total · Data Release 46.0 · mapped to Uterine Carcinosarcoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	gdc
2	PIK3CA	Ssm	46	57	80.7%	gdc
3	MELTF	Ssm	46	57	80.7%	gdc
7	ATP13A5	Ssm	45	57	78.9%	gdc
9	MB21D2	Ssm	45	57	78.9%	gdc
8	YEATS2	Ssm	45	57	78.9%	gdc
10	ATP13A4	Ssm	45	57	78.9%	gdc
11	RNF168	Ssm	45	57	78.9%	gdc
21	PSMA7	Ssm	45	57	78.9%	gdc
20	OPA1	Ssm	45	57	78.9%	gdc
19	FBXO45	Ssm	45	57	78.9%	gdc
18	GATA5	Ssm	45	57	78.9%	gdc
17	OSTN	Ssm	45	57	78.9%	gdc
16	TRA2B	Ssm	45	57	78.9%	gdc
15	APOD	Ssm	45	57	78.9%	gdc
14	EEF1AKMT4-ECE2	Ssm	45	57	78.9%	gdc
13	MUC4	Ssm	45	57	78.9%	gdc
12	FGF12	Ssm	45	57	78.9%	gdc
4	SENP5	Ssm	45	57	78.9%	gdc
5	LAMA5	Ssm	45	57	78.9%	gdc
6	ADRM1	Ssm	45	57	78.9%	gdc
24	DVL3	Ssm	44	57	77.2%	gdc
23	PIGX	Ssm	44	57	77.2%	gdc
22	SS18L1	Ssm	44	57	77.2%	gdc
30	OSBPL2	Ssm	44	57	77.2%	gdc
29	RBBP8NL	Ssm	44	57	77.2%	gdc
28	AHSG	Ssm	44	57	77.2%	gdc
27	SLC51A	Ssm	44	57	77.2%	gdc
26	TNK2	Ssm	44	57	77.2%	gdc
25	NCBP2AS2	Ssm	44	57	77.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014Johns Hopkins

22 cases with simple somatic mutation data · 22 cases total · 2026-01-16 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	22	72.7%	cbioportal
2	PIK3CA	Ssm	9	22	40.9%	cbioportal
3	PTEN	Ssm	9	22	40.9%	cbioportal
4	ARID1A	Ssm	8	22	36.4%	cbioportal
7	PXDNL	Ssm	6	22	27.3%	cbioportal
5	KMT2C	Ssm	6	22	27.3%	cbioportal
6	KRAS	Ssm	6	22	27.3%	cbioportal
8	TTN	Ssm	6	22	27.3%	cbioportal
21	SPEG	Ssm	5	22	22.7%	cbioportal
20	PLEC	Ssm	5	22	22.7%	cbioportal
19	MDN1	Ssm	5	22	22.7%	cbioportal
18	LTBP2	Ssm	5	22	22.7%	cbioportal
17	LRP2	Ssm	5	22	22.7%	cbioportal
16	HMCN1	Ssm	5	22	22.7%	cbioportal
15	FBXW7	Ssm	5	22	22.7%	cbioportal
13	CNTNAP2	Ssm	5	22	22.7%	cbioportal
14	FAM135B	Ssm	5	22	22.7%	cbioportal
9	APOB	Ssm	5	22	22.7%	cbioportal
10	BCOR	Ssm	5	22	22.7%	cbioportal
11	BLTP1	Ssm	5	22	22.7%	cbioportal
12	CDHR3	Ssm	5	22	22.7%	cbioportal
24	URB1	Ssm	5	22	22.7%	cbioportal
23	TRRAP	Ssm	5	22	22.7%	cbioportal
22	SPTBN5	Ssm	5	22	22.7%	cbioportal
30	ADNP	Ssm	4	22	18.2%	cbioportal
25	A2M	Ssm	4	22	18.2%	cbioportal
26	ABI3BP	Ssm	4	22	18.2%	cbioportal
27	ADAMTSL4	Ssm	4	22	18.2%	cbioportal
28	ADGRF4	Ssm	4	22	18.2%	cbioportal
29	ADGRG4	Ssm	4	22	18.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Carcinosarcoma (TCGA, Firehose Legacy) ucs_tcgaTCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-01-13 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	FRG1BP	Ssm	21	57	36.8%	cbioportal
4	PIK3CA	Ssm	20	57	35.1%	cbioportal
5	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	MUC4	Ssm	13	57	22.8%	cbioportal
7	PTEN	Ssm	11	57	19.3%	cbioportal
9	TTN	Ssm	10	57	17.5%	cbioportal
8	CHD4	Ssm	10	57	17.5%	cbioportal
10	ARID1A	Ssm	8	57	14%	cbioportal
12	LRP1B	Ssm	7	57	12.3%	cbioportal
11	KRAS	Ssm	7	57	12.3%	cbioportal
13	MUC17	Ssm	7	57	12.3%	cbioportal
16	KMT2D	Ssm	6	57	10.5%	cbioportal
14	ARHGAP35	Ssm	6	57	10.5%	cbioportal
15	FLNA	Ssm	6	57	10.5%	cbioportal
17	MGAM	Ssm	6	57	10.5%	cbioportal
18	MUC16	Ssm	6	57	10.5%	cbioportal
19	PIK3R1	Ssm	6	57	10.5%	cbioportal
20	RB1	Ssm	6	57	10.5%	cbioportal
21	SYNE1	Ssm	6	57	10.5%	cbioportal
22	VPS13B	Ssm	6	57	10.5%	cbioportal
23	ZBTB7B	Ssm	6	57	10.5%	cbioportal
24	ZNF814	Ssm	6	57	10.5%	cbioportal
25	ATP4A	Ssm	5	57	8.8%	cbioportal
28	FER1L6	Ssm	5	57	8.8%	cbioportal
30	LRP2	Ssm	5	57	8.8%	cbioportal
29	FLG	Ssm	5	57	8.8%	cbioportal
27	FCGBP	Ssm	5	57	8.8%	cbioportal
26	DOP1A	Ssm	5	57	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Carcinosarcoma (TCGA, PanCancer Atlas) ucs_tcga_pan_can_atlas_2018TCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-06-05 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	TTN	Ssm	11	57	19.3%	cbioportal
7	CHD4	Ssm	10	57	17.5%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
13	KMT2D	Ssm	6	57	10.5%	cbioportal
10	AHNAK	Ssm	6	57	10.5%	cbioportal
11	ARHGAP35	Ssm	6	57	10.5%	cbioportal
12	FLNA	Ssm	6	57	10.5%	cbioportal
14	MGAM	Ssm	6	57	10.5%	cbioportal
15	MUC16	Ssm	6	57	10.5%	cbioportal
16	PIK3R1	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
18	VPS13B	Ssm	6	57	10.5%	cbioportal
19	ZBTB7B	Ssm	6	57	10.5%	cbioportal
21	FER1L6	Ssm	5	57	8.8%	cbioportal
22	FLG	Ssm	5	57	8.8%	cbioportal
23	LRP1B	Ssm	5	57	8.8%	cbioportal
20	DOP1A	Ssm	5	57	8.8%	cbioportal
24	LRP2	Ssm	5	57	8.8%	cbioportal
25	MUC17	Ssm	5	57	8.8%	cbioportal
26	RB1	Ssm	5	57	8.8%	cbioportal
30	COL11A1	Ssm	4	57	7%	cbioportal
27	ABCA12	Ssm	4	57	7%	cbioportal
28	ADAMTSL1	Ssm	4	57	7%	cbioportal
29	BRWD1	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor (TCGA GDC, 2025) ucs_tcga_gdcTCGA GDC

57 cases with simple somatic mutation data · 57 cases total · 2026-01-14 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	49	57	86%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	CHD4	Ssm	10	57	17.5%	cbioportal
7	PIK3R1	Ssm	9	57	15.8%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
10	TTN	Ssm	7	57	12.3%	cbioportal
12	ARHGAP35	Ssm	6	57	10.5%	cbioportal
18	ZBTB7B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	MGAM	Ssm	6	57	10.5%	cbioportal
15	LRP2	Ssm	6	57	10.5%	cbioportal
14	KMT2D	Ssm	6	57	10.5%	cbioportal
13	FLNA	Ssm	6	57	10.5%	cbioportal
11	AHNAK	Ssm	6	57	10.5%	cbioportal
22	RB1	Ssm	5	57	8.8%	cbioportal
23	VPS13B	Ssm	5	57	8.8%	cbioportal
19	DOP1A	Ssm	5	57	8.8%	cbioportal
20	MUC16	Ssm	5	57	8.8%	cbioportal
21	MUC17	Ssm	5	57	8.8%	cbioportal
25	ADAMTSL1	Ssm	4	57	7%	cbioportal
28	CUBN	Ssm	4	57	7%	cbioportal
27	COPB1	Ssm	4	57	7%	cbioportal
26	BRWD1	Ssm	4	57	7%	cbioportal
24	ABCA12	Ssm	4	57	7%	cbioportal
30	DPP10	Ssm	4	57	7%	cbioportal
29	DNAH2	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Wilms' Tumor (TARGET GDC, 2025) wt_target_gdcTARGET GDC

42 cases with simple somatic mutation data · 132 cases total · 2026-01-19 · mapped to Wilms Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	13	42	31%	cbioportal
2	TTN	Ssm	4	42	9.5%	cbioportal
3	BCOR	Ssm	3	42	7.1%	cbioportal
18	KHDRBS3	Ssm	2	42	4.8%	cbioportal
19	KMT2D	Ssm	2	42	4.8%	cbioportal
20	LPCAT2	Ssm	2	42	4.8%	cbioportal
21	MAMDC4	Ssm	2	42	4.8%	cbioportal
22	MLLT1	Ssm	2	42	4.8%	cbioportal
23	MMRN2	Ssm	2	42	4.8%	cbioportal
24	MTMR3	Ssm	2	42	4.8%	cbioportal
25	RNF115	Ssm	2	42	4.8%	cbioportal
26	RUSC2	Ssm	2	42	4.8%	cbioportal
27	SHROOM2	Ssm	2	42	4.8%	cbioportal
28	SLC75A1	Ssm	2	42	4.8%	cbioportal
29	TENM1	Ssm	2	42	4.8%	cbioportal
30	TNRC18	Ssm	2	42	4.8%	cbioportal
4	ABCC11	Ssm	2	42	4.8%	cbioportal
5	ADCY5	Ssm	2	42	4.8%	cbioportal
6	AOAH	Ssm	2	42	4.8%	cbioportal
7	ASB5	Ssm	2	42	4.8%	cbioportal
8	CARD10	Ssm	2	42	4.8%	cbioportal
9	CCER1	Ssm	2	42	4.8%	cbioportal
10	CDC73	Ssm	2	42	4.8%	cbioportal
11	CHD4	Ssm	2	42	4.8%	cbioportal
12	CREBBP	Ssm	2	42	4.8%	cbioportal
13	CSMD2	Ssm	2	42	4.8%	cbioportal
14	DNHD1	Ssm	2	42	4.8%	cbioportal
15	DSCAML1	Ssm	2	42	4.8%	cbioportal
16	FAM184B	Ssm	2	42	4.8%	cbioportal
17	GTF2H3	Ssm	2	42	4.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-19