Hematologic Malignancy
B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like
CI-CAN-00004540Explore in graph →
Hematologic3 active trials80 evidence items
- NCIt
- C129787
- OncoTree
- BLLBCRABL1L
- DOID
- 0080650
- UMLS CUI
- C4329382
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Hematologic Malignancy
CI-CAN-00004540Explore in graph →
Variants & evidence
128 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| ABL1 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 1 | submitted | EID11616B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (12.1 years old) with a… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| ABL1 Fusion6 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID9074Transcriptome and whole genome sequencing were performed on 15 cases of B-lymphoblastic leukemia/lymphoma (B-ALL) that were previously shown to have a BCR-ABL1-like (Ph-like) expression signature. Two… (full text at CIViC) PMID 22897847 · Roberts et al., 2012 · Open in CIViC | civic |
| Dasatinib | Predictive | B | Supports Sensitivity Response | 3 | submitted | EID13328Of 40 patients with BCR::ABL1-like (Ph-like) B-cell acute lymphoblastic leukemia (B-ALL), one 16-year-old male was found to have a NUP214::ABL1 fusion identified by genomic profiling (RT-PCR, next-gen… (full text at CIViC) PMID 25049327 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID13327A 26-year-old female with Philadelphia chromosome-like (Ph-like) B-cell acute lymphoblastic leukemia (B-ALL) had a NUP214::ABL1 fusion detected by a next-generation sequencing panel experienced persis… | |
| JAK2 Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID7997To identify potentially druggable kinase fusions, this study of 278 B-ALL patients (all BCR-ABL1 negative), 34 (12.2%) harbored an IKZF1 deletion as determined by MLPA. Sufficient RNA from 16/34 of th… (full text at CIViC) PMID 26404892 · Yano et al., 2015 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 2 | accepted | EID8104In this study involving 373 high risk pediatric B-ALL cases with no recurrent fusions, 29 were kinase-fusion positive as determined by mRNA-seq or mRT-PCR and validated by RT-PCR and Sanger. One case,… (full text at CIViC) PMID 27176795 · Imamura et al., 2016 · Open in CIViC | civic |
| CRLF2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 1 | accepted | EID11622In this 2014 study by Roberts et al., a genomic analysis of 1725 patients with precursor B-cell acute lymphoblastic leukemia (B-ALL) was conducted to define the genetic landscape of the Philadelphia c… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| ABL2 Fusion2 | |||||||
| (oncogenic) | Oncogenic | C | Supports Oncogenicity | 2 | submitted | EID9721In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Oncogenic | C | Supports Oncogenicity | 2 | submitted | EID12872In a study using whole genome, exome and transcriptome sequencing of 2,754 childhood ALL patients, one patient with Ph-like B-ALL had PAG1::ABL2 reported. Patient ID was SJBALL020980. RNAseq, WES, WGS… (full text at CIViC) PMID 36050548 · Brady et al., 2022 · Open in CIViC | civic |
| JAK2 Fusion6 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID7699In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID7700In this study which included 1389 cases of high-risk pediatric B-ALL, 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on CRLF2 n… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | submitted | EID7701This study evaluated the prevalence and outcome of Ph-like ALL subtype in patients wiiht standard-risk (SR) disease. A cohort of 1023 SR cases from the Children's Oncology Group AALL0331 clinical tria… | |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7704The PCM1-JAK2 fusion is typically associated with 'myeloid/lymphoid neoplasms with eosinophilia and gene rearrangements', which is a specific disease entity according to WHO classification. However, i… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7673In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID8099In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease.The PPFIBP1-JAK2 fusion is rare; In this study inv… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
| ABL1 Fusion3 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID9076This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on Ph-like… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 2 | submitted | EID11617B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 2 of 2 patients (ages 2.7 and 12.… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| Dasatinib | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID9211This retrospective study reported the outcome of 24 patients with Ph-like acute lymphoblastic leukemia (Ph-like ALL) harboring ABL-class fusions, who were treated with a combination of tyrosine kinase… | |
| ABL1 Fusion6 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 2 | accepted | EID9075This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on Ph-like… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 2 | accepted | EID9162The study evaluated 15 B-ALL cases which were previously identified as Ph-like using prediction analysis of microarrays (PAM). Paired-end messenger RNA sequencing (RNA-seq) was performed to identify u… (full text at CIViC) PMID 22897847 · Roberts et al., 2012 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 1 | submitted | EID11618B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6.9 years old) with a… | |
| ABL2 Fusion2 | |||||||
| Dasatinib | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID7251The RCSD1-ABL2 fusion was identified in a 5 yo boy with Ph-like B-ALL and Klinefelter syndrome. Following standard induction therapy the patient had an MRD of 1.2% in bone marrow, and continued to be … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| Imatinib | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID9772A 5 year-old male patient with B-ALL was described with an initial WBC of 57,700 (Supplementary Appendix 2). Chromosome analysis showed 47,XXYc with a confirmed diagnosis of Klinefelter syndrome. FISH… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7707This study included 1389 cases of high-risk pediatric B-ALL, out of which 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on the… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7996In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. The SMU1-JAK2 fusion is rare; in this study invol… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7998In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. The SNX29-JAK2 fusion is rare; in this study invo… (full text at CIViC) PMID 27428428 · Liu et al., 2016 · Open in CIViC | civic |
| ABL1 Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID9177This retrospective study intended to clarify clinical characteristics of patients with B-lymphoblastic leukemia/lymphoma (B-ALL) and kinase fusions that are not well described (excluding ETV6-RUNX1, E… (full text at CIViC) PMID 27176795 · Imamura et al., 2016 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID9178In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| CSF1R Fusion2 | |||||||
| (prognostic) | Prognostic | B | Supports Better Outcome | 3 | submitted | EID9767Patients originated from 4 international (UK, Netherlands, Germany, and US) studies, and included 16 B-cell precursor ALL (B-ALL) patients (aged 2-29 years) with SSBP2-CSF1R fusions arising from diffe… (full text at CIViC) PMID 33197935 · Schwab et al., 2021 · Open in CIViC | civic |
| (diagnostic) | Diagnostic | B | Supports Positive | 2 | submitted | EID9803A multicenter, retrospective study that included 1389 consecutively enrolled, newly diagnosed patients with B-lineage acute lymphoblastic leukemia (B-ALL). There were 3 patients that harbored SSPB2-CS… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion4 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 4 | accepted | EID8103In this study which included 1389 cases of high-risk pediatric B-ALL, 284 were identified by TaqMan Low Density Array to have a Ph-like gene expression signature. RT-PCR or RNAseq performed on CRLF2 n… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID8100In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease.The SSBP2-JAK2 fusion is rare; In this study invol… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 1 | submitted | EID11624B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (14 years old) with an … | |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7674In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| CSF1R Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID9361This study included 1389 cases of high-risk pediatric B-ALL, of which 284 were identified by TaqMan Low Density Array to have a BCR-ABL1-like (Ph-like) gene expression signature. RT-PCR or RNAseq perf… (full text at CIViC) PMID 28408464 · Reshmi et al., 2017 · Open in CIViC | civic |
| JAK2 Fusion2 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 4 | submitted | EID7703In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. The TERF2-JAK2 fusionis rare. This study was cond… (full text at CIViC) PMID 27894077 · Boer et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID7702In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| PDGFRB Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Does Not Support Positive | 1 | submitted | EID11626B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (6 years old) with a TN… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| JAK2 Fusion1 | |||||||
| (diagnostic) | Diagnostic | C | Supports Positive | 3 | accepted | EID7675In the study involving 1725 B-ALL patients, 264 were identified by microarray-based algorithm to have a Ph-like expression signature. Next generation sequencing (RNAseq, WGS, and/or WES) performed on … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| TYK2 S431G1 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | rejected | EID12804In this 2020 study, the authors analyzed bone marrow samples from 62 B-ALL patients at diagnosis using next-generation sequencing (NGS) to search for disease-associated TYK2 gene variants. The patient… (full text at CIViC) PMID 33260630 · Turrubiartes-Martínez et al., 2020 · Open in CIViC | civic |
Data updated 23 minutes agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.
PMID 31014138 · Aldoss et al., 2019 · Open in CIViC
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| Dasatinib + NilotinibSequential | Predictive | C | Supports Sensitivity Response | 3 | submitted | EID13329A 21-year-old patient with refractory B-cell acute lymphoblastic leukemia (B-ALL) had a NUP214::ABL1 fusion identified by clinical next-generation sequencing failed multiple prior treatment regimens, … (full text at CIViC) PMID 37933765 · Shumock et al., 2023 · Open in CIViC | civic |
| Dasatinib + Dexamethasone + VincristineCombination | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID7208A 15-year-old girl with B-cell precursor ALL was placed into the very high risk group after showing corticoid resistance on treatment day 8, and induction failure on day 35 (MRD >0.01). The patient re… (full text at CIViC) PMID 26681761 · Duployez et al., 2016 · Open in CIViC | civic |
| Dasatinib + ImatinibCombination | Predictive | B | Supports Sensitivity Response | 3 | submitted | EID13330In a cohort of six patients with NUP214::ABL1-positive Ph-like B-ALL, detected by multiplex molecular assays for fusion transcript identification, including RNA sequencing, treatment with ABL-directed… (full text at CIViC) PMID 31434701 · Tanasi et al., 2019 · Open in CIViC | civic |
PMID 29997224 · Roberts et al., 2018 · Open in CIViC
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| 〃 | Diagnostic | C | Supports Positive | 3 | submitted | EID8098In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. In this study involving 798 B-ALL patients of whi… (full text at CIViC) PMID 27870571 · Roberts et al., 2017 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 3 | accepted | EID8105In B-lymphoblastic leukemia/lymphoma (B-ALL), the presence of this fusion is associated with so-called BCR/ABL1 like (Ph-like) subtype of the disease. In this study involving 373 high risk pediatric B… (full text at CIViC) PMID 27176795 · Imamura et al., 2016 · Open in CIViC | civic |
| 〃 | Diagnostic | C | Supports Positive | 1 | submitted | EID11623B-ALL cases with high-risk clinical features or suggestion of a kinase rearrangement were subjected to low density gene expression array to determine Ph-like status. 1 patient (5.3 years old) with a P… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
PMID 31434701 · Tanasi et al., 2019 · Open in CIViC
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PMID 25207766 · Roberts et al., 2014 · Open in CIViC
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| Dasatinib | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID7249The ABL1-RCSD1 fusion was identified in a 6 yo boy with Ph-like B-ALL and hyperleukocytosis. Following standard induction therapy the patient had an MRD of 16.4% in bone marrow, indicating a poor resp… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| Imatinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID7248The RCSD1-ABL1 fusion was identified in a 6 yo boy with Ph-like B-ALL (expression signature verified by low density gene expression array) and hyperleukocytosis. Following standard induction therapy t… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
| Tyrosine Kinase Inhibitor | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID9169Authors reported a 15-year-old female diagnosed with B-ALL with the t(1;9)(q24;q34.1). RNAseq data were consistent with a fusion between the exon 3 of RCSD1 and exon 4 of ABL1, resulting in the format… (full text at CIViC) PMID 27855558 · Yap et al., 2017 · Open in CIViC | civic |
PMID 25207766 · Roberts et al., 2014 · Open in CIViC
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| Ruxolitinib | Predictive | C | Supports Sensitivity Response | 3 | accepted | EID7257The SSBP2-JAK2 fusion was identified in a 14 yo male with Ph-like B-ALL, a t(5;9)(q12;p1?3), and a WBC of 160,000. Following 4-drug induction therapy the patient had an MRD of 5.5%, indicating a poor … (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |