SMAD4

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
SMAD4 associated with …ASSOCIATED_WITH5 of 5
→ associated with	Malignant Colorectal Neoplasmsubtype 2 source records aggregated	supports	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ associated with	Malignant Pancreatic Neoplasmcancer	supports

SMAD4 has variant …HAS_VARIANTderived200 of 2,479show all (up to 200)
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm,Pancreatic Adenocarcinoma	2	Curated	civic	graph →
→ has variant	Deletiondeletion_cna 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Expressionexpression 1 accepted CIViC evidence items	—	—	Pancreatic Ductal Adenocarcinoma	1	Curated	civic	graph →
→ has variant	LOSSdeletion_cna 1 accepted CIViC evidence items	—	—	Malignant Pancreatic Neoplasm	1	Curated	civic	graph →
→ has variant	R361CSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	Underexpressionexpression 1 accepted CIViC evidence items	—	—	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Alterationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	c.403C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D351HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D493HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D537YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E330ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E330KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	FRAMESHIFT MUTATIONindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G252*SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G386DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G419VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	H132YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Loss-of-function no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.(?_51030213)_(51030623_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.(?_51030213)_(51078477_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.51058125deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.(?_51065417)_(51067193_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.(?_51067019)_(51085042_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.(?_51076628)_(51078477_?)deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.51076638deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.10:g.51078424_51078439delinsCAindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.9:g.(?_48556583)_(48604847_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000018.9:g.(?_48603008)_(48611412_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.5(SMAD4):c.(?_-1)_249+?dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.5(SMAD4):c.1571_1574delGGATins19 (p.?)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.5(SMAD4):c.(?_-538)_1139+?deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.5(SMAD4):c.731_732insGCCC(p.Gln245Profs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1000C>A (p.Gln334Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1000C>G (p.Gln334Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1000C>T (p.Gln334Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1001A>G (p.Gln334Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1002G>A (p.Gln334=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1002G>C (p.Gln334His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1002G>T (p.Gln334His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1004_1006dup (p.Val335_Gly336insVal)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1004T>G (p.Val335Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1005A>G (p.Val335=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1006G>C (p.Gly336Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1007G>A (p.Gly336Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1008A>G (p.Gly336=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1009G>C (p.Glu337Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1010_1015del (p.Glu337_Phe339delinsVal)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1010A>G (p.Glu337Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1010del (p.Glu337fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.10_11del (p.Met4fs)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1011G>A (p.Glu337=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1013C>G (p.Thr338Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1014A>C (p.Thr338=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1014A>G (p.Thr338=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1014A>T (p.Thr338=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1017dup (p.Lys340Ter)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1018A>G (p.Lys340Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1019dup (p.Val341fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1020G>A (p.Lys340=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1023del (p.Pro342fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1025C>T (p.Pro342Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1026T>A (p.Pro342=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1028C>G (p.Ser343Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1029A>G (p.Ser343=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.102A>G (p.Thr34=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.102A>T (p.Thr34=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1030A>G (p.Ser344Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1031G>A (p.Ser344Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1034G>A (p.Cys345Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1034G>C (p.Cys345Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1035C>T (p.Cys345=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1036C>A (p.Pro346Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.*1036C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1036C>G (p.Pro346Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1036C>T (p.Pro346Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1037C>G (p.Pro346Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1037del (p.Pro346fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1038T>G (p.Pro346=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1039A>G (p.Ile347Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1040T>C (p.Ile347Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1041T>C (p.Ile347=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1041T>G (p.Ile347Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1042_1043del (p.Val348fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1042G>A (p.Val348Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1045A>G (p.Thr349Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1045dup (p.Thr349fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1046C>T (p.Thr349Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1047T>A (p.Thr349=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1047T>C (p.Thr349=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1049T>C (p.Val350Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.104T>A (p.Phe35Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.104T>C (p.Phe35Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1050T>C (p.Val350=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1050T>G (p.Val350=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1051G>C (p.Asp351His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1052A>T (p.Asp351Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1054G>A (p.Gly352Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1056A>C (p.Gly352=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1058_1061del (p.Tyr353fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1058A>C (p.Tyr353Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1058A>G (p.Tyr353Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1058A>T (p.Tyr353Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1059C>A (p.Tyr353Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1059C>G (p.Tyr353Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1059C>T (p.Tyr353=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.105T>C (p.Phe35=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1060_1066delinsT (p.Val354_Pro356delinsSer)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1060G>A (p.Val354Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1061T>A (p.Val354Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1063_1064insGACCCTTCTGGAGGAGATCGCTTTTGTTTGGGTCAACTCTCCAATGTCCACAGGACAGAAGCCATTGAGAGAGCAAGGTATTGATTG (p.Asp355delinsGlyProPheTrpArgArgSerLeuLeuPheGlySerThrLeuGlnCysProGlnAspArgSerHisTer)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1063G>A (p.Asp355Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1064A>G (p.Asp355Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1064A>T (p.Asp355Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1065C>G (p.Asp355Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1066C>T (p.Pro356Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1067C>T (p.Pro356Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1067del (p.Pro356fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1067dup (p.Ser357fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.*1067G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1069T>C (p.Ser357Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1070C>T (p.Ser357Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1072G>A (p.Gly358Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1072G>T (p.Gly358Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1075G>C (p.Gly359Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1077A>C (p.Gly359=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1078G>C (p.Asp360His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.107C>T (p.Ala36Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.107del (p.Ala36fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1080T>C (p.Asp360=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1081C>A (p.Arg361Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1081C>G (p.Arg361Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1081C>T (p.Arg361Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1082G>A (p.Arg361His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1086T>C (p.Phe362=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1087T>C (p.Cys363Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1087T>G (p.Cys363Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1088_1090del (p.Cys363del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1088G>A (p.Cys363Tyr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1089T>C (p.Cys363=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.108A>C (p.Ala36=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.108A>G (p.Ala36=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1090T>C (p.Leu364=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1091T>C (p.Leu364Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1091T>G (p.Leu364Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1092G>A (p.Leu364=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1093G>C (p.Gly365Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1095T>C (p.Gly365=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1096C>T (p.Gln366Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1098A>G (p.Gln366=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1099C>G (p.Leu367Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1099C>T (p.Leu367Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.-10A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.*10C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.*10C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.-10deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1100T>A (p.Leu367His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1101C>A (p.Leu367=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1101C>T (p.Leu367=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1102T>A (p.Ser368Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1103_1114del (p.Ser368_Arg372delinsTrp)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1103C>T (p.Ser368Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1104C>G (p.Ser368=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1106A>G (p.Asn369Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1106A>T (p.Asn369Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1107T>C (p.Asn369=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.110A>G (p.Lys37Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1110C>A (p.Val370=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1112A>G (p.His371Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1113C>T (p.His371=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1118_1120delinsA (p.Thr373fs)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1118C>T (p.Thr373Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1119A>T (p.Thr373=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.112_121delinsGAGC (p.Arg38_Glu41delinsGluGln)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1122A>G (p.Glu374=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1123G>A (p.Ala375Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1124C>A (p.Ala375Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1124C>T (p.Ala375Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1125_1128dup (p.Glu377delinsHisTer)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1125C>T (p.Ala375=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1126A>G (p.Ile376Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1127T>C (p.Ile376Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1128T>C (p.Ile376=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.112del (p.Arg38fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.-113_-106delinsCTAAAGGGGCAAATACCTAAATGTTCTAAAGGGGCAAAATATCAACTACAATACTCGGTTTTAGCAGTCAAAATATAAGTTTGTTCCTAAATTCAAATTTAAATACGTATATTAAAAATGTCTGATTCTTTAACCTTATTTAAAGTCGCGGGCTATCTTCCAAATTTATAATTTAACTTACAAAAATTGAAACACTATTGAGATCCTTTTCCCTTTATGTTTCTTAGGATGAAAGCAAAGTCTACTTACCAATTCCAGGTGATACAACTCGTTCGTAGTGATATGGATTCACACAGACACTATCACATTTTAAGTCAAACGCATACTGACAATATTTAACATGTTTTAGTTCATTTTTGTGAAGATCAGGCCACCTCCAGAGAGGTGindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1131G>A (p.Glu377=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1134_1135del (p.Arg378fs)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1135G>C (p.Ala379Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1136C>T (p.Ala379Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1137A>G (p.Ala379=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1138A>G (p.Arg380Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1138A>T (p.Arg380Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1138del (p.Arg380fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+10G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+10G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+1_1139+4dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+12A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+13T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+13T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005359.6(SMAD4):c.1139+14A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

SMAD4 has variant …HAS_VARIANTderived200 of 2,479show all (up to 200)

→ has variant

Mutationother

2 accepted CIViC evidence items

—

Malignant Colorectal Neoplasm,Pancreatic Adenocarcinoma

Curated

civic

graph →

→ has variant

Deletiondeletion_cna

1 accepted CIViC evidence items

—

Malignant Colorectal Neoplasm

Curated

civic

graph →

→ has variant

Expressionexpression

1 accepted CIViC evidence items

—

Pancreatic Ductal Adenocarcinoma

Curated

civic

graph →

→ has variant

LOSSdeletion_cna

1 accepted CIViC evidence items

—

Malignant Pancreatic Neoplasm

Curated

civic

graph →

→ has variant

R361CSNV

1 accepted CIViC evidence items

—

not mapped

Curated

civic

graph →

→ has variant

Underexpressionexpression

1 accepted CIViC evidence items

—

Head and Neck Squamous Cell Carcinoma

Curated

civic

graph →

→ has variant

Alterationother

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

c.403C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

D351HSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

D493HSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

D537YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

E330ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

E330KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

FRAMESHIFT MUTATIONindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

G252*SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

G386DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

G419VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

H132YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

Loss-of-function

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.(?_51030213)_(51030623_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.(?_51030213)_(51078477_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.51058125deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.(?_51065417)_(51067193_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.(?_51067019)_(51085042_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.(?_51076628)_(51078477_?)deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.51076638deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.10:g.51078424_51078439delinsCAindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.9:g.(?_48556583)_(48604847_?)dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NC_000018.9:g.(?_48603008)_(48611412_?)dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.5(SMAD4):c.(?_-1)_249+?dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.5(SMAD4):c.1571_1574delGGATins19 (p.?)indel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.5(SMAD4):c.(?_-538)_1139+?deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.5(SMAD4):c.731_732insGCCC(p.Gln245Profs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1000C>A (p.Gln334Lys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1000C>G (p.Gln334Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1000C>T (p.Gln334Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1001A>G (p.Gln334Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1002G>A (p.Gln334=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1002G>C (p.Gln334His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1002G>T (p.Gln334His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1004_1006dup (p.Val335_Gly336insVal)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1004T>G (p.Val335Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1005A>G (p.Val335=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1006G>C (p.Gly336Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1007G>A (p.Gly336Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1008A>G (p.Gly336=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1009G>C (p.Glu337Gln)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1010_1015del (p.Glu337_Phe339delinsVal)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1010A>G (p.Glu337Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1010del (p.Glu337fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.10_11del (p.Met4fs)other

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1011G>A (p.Glu337=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1013C>G (p.Thr338Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1014A>C (p.Thr338=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1014A>G (p.Thr338=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1014A>T (p.Thr338=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1017dup (p.Lys340Ter)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1018A>G (p.Lys340Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1019dup (p.Val341fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1020G>A (p.Lys340=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1023del (p.Pro342fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1025C>T (p.Pro342Leu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1026T>A (p.Pro342=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1028C>G (p.Ser343Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1029A>G (p.Ser343=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.102A>G (p.Thr34=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.102A>T (p.Thr34=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1030A>G (p.Ser344Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1031G>A (p.Ser344Asn)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1034G>A (p.Cys345Tyr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1034G>C (p.Cys345Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1035C>T (p.Cys345=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1036C>A (p.Pro346Thr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.*1036C>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1036C>G (p.Pro346Ala)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1036C>T (p.Pro346Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1037C>G (p.Pro346Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1037del (p.Pro346fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1038T>G (p.Pro346=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1039A>G (p.Ile347Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1040T>C (p.Ile347Thr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1041T>C (p.Ile347=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1041T>G (p.Ile347Met)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1042_1043del (p.Val348fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1042G>A (p.Val348Ile)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1045A>G (p.Thr349Ala)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1045dup (p.Thr349fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1046C>T (p.Thr349Ile)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1047T>A (p.Thr349=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1047T>C (p.Thr349=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1049T>C (p.Val350Ala)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.104T>A (p.Phe35Tyr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.104T>C (p.Phe35Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1050T>C (p.Val350=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1050T>G (p.Val350=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1051G>C (p.Asp351His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1052A>T (p.Asp351Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1054G>A (p.Gly352Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1056A>C (p.Gly352=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1058_1061del (p.Tyr353fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1058A>C (p.Tyr353Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1058A>G (p.Tyr353Cys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1058A>T (p.Tyr353Phe)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1059C>A (p.Tyr353Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1059C>G (p.Tyr353Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1059C>T (p.Tyr353=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.105T>C (p.Phe35=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1060_1066delinsT (p.Val354_Pro356delinsSer)indel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1060G>A (p.Val354Met)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1061T>A (p.Val354Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1063_1064insGACCCTTCTGGAGGAGATCGCTTTTGTTTGGGTCAACTCTCCAATGTCCACAGGACAGAAGCCATTGAGAGAGCAAGGTATTGATTG (p.Asp355delinsGlyProPheTrpArgArgSerLeuLeuPheGlySerThrLeuGlnCysProGlnAspArgSerHisTer)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1063G>A (p.Asp355Asn)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1064A>G (p.Asp355Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1064A>T (p.Asp355Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1065C>G (p.Asp355Glu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1066C>T (p.Pro356Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1067C>T (p.Pro356Leu)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1067del (p.Pro356fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1067dup (p.Ser357fs)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.*1067G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1069T>C (p.Ser357Pro)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1070C>T (p.Ser357Phe)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1072G>A (p.Gly358Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1072G>T (p.Gly358Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1075G>C (p.Gly359Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1077A>C (p.Gly359=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1078G>C (p.Asp360His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.107C>T (p.Ala36Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.107del (p.Ala36fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1080T>C (p.Asp360=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1081C>A (p.Arg361Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1081C>G (p.Arg361Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1081C>T (p.Arg361Cys)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1082G>A (p.Arg361His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1086T>C (p.Phe362=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1087T>C (p.Cys363Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1087T>G (p.Cys363Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1088_1090del (p.Cys363del)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1088G>A (p.Cys363Tyr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1089T>C (p.Cys363=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.108A>C (p.Ala36=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.108A>G (p.Ala36=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1090T>C (p.Leu364=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1091T>C (p.Leu364Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1091T>G (p.Leu364Trp)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1092G>A (p.Leu364=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1093G>C (p.Gly365Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1095T>C (p.Gly365=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1096C>T (p.Gln366Ter)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1098A>G (p.Gln366=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1099C>G (p.Leu367Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1099C>T (p.Leu367Phe)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.-10A>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.*10C>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.*10C>TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.-10deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1100T>A (p.Leu367His)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1101C>A (p.Leu367=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1101C>T (p.Leu367=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1102T>A (p.Ser368Thr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1103_1114del (p.Ser368_Arg372delinsTrp)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1103C>T (p.Ser368Phe)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1104C>G (p.Ser368=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1106A>G (p.Asn369Ser)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1106A>T (p.Asn369Ile)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1107T>C (p.Asn369=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.110A>G (p.Lys37Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1110C>A (p.Val370=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1112A>G (p.His371Arg)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1113C>T (p.His371=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1118_1120delinsA (p.Thr373fs)indel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1118C>T (p.Thr373Ile)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1119A>T (p.Thr373=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.112_121delinsGAGC (p.Arg38_Glu41delinsGluGln)indel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1122A>G (p.Glu374=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1123G>A (p.Ala375Thr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1124C>A (p.Ala375Asp)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1124C>T (p.Ala375Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1125_1128dup (p.Glu377delinsHisTer)insertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1125C>T (p.Ala375=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1126A>G (p.Ile376Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1127T>C (p.Ile376Thr)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1128T>C (p.Ile376=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.112del (p.Arg38fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.-113_-106delinsCTAAAGGGGCAAATACCTAAATGTTCTAAAGGGGCAAAATATCAACTACAATACTCGGTTTTAGCAGTCAAAATATAAGTTTGTTCCTAAATTCAAATTTAAATACGTATATTAAAAATGTCTGATTCTTTAACCTTATTTAAAGTCGCGGGCTATCTTCCAAATTTATAATTTAACTTACAAAAATTGAAACACTATTGAGATCCTTTTCCCTTTATGTTTCTTAGGATGAAAGCAAAGTCTACTTACCAATTCCAGGTGATACAACTCGTTCGTAGTGATATGGATTCACACAGACACTATCACATTTTAAGTCAAACGCATACTGACAATATTTAACATGTTTTAGTTCATTTTTGTGAAGATCAGGCCACCTCCAGAGAGGTGindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1131G>A (p.Glu377=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1134_1135del (p.Arg378fs)other

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1135G>C (p.Ala379Pro)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1136C>T (p.Ala379Val)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1137A>G (p.Ala379=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1138A>G (p.Arg380Gly)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1138A>T (p.Arg380Trp)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1138del (p.Arg380fs)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+10G>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+10G>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+1_1139+4dupinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+12A>GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+13T>ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+13T>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_005359.6(SMAD4):c.1139+14A>CSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

SMAD4 altered in cohorts of …ALTERED_INderived12 of 12
→ altered in cohorts of	Esophageal Carcinoma 128 / 185 cases (69 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Gallbladder Carcinoma 52 / 244 cases (21 %) · ssm · gbc_mskcc_2022 · largest of 2 cohorts	—	—	Gallbladder Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Ampulla of Vater Carcinoma 29 / 160 cases (18 %) · ssm · ampca_bcm_2016	—	—	Ampulla of Vater Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 173 / 1,134 cases (15 %) · ssm · crc_msk_2017 · largest of 8 cohorts	—	—	Colorectal Adenocarcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 1,078 / 7,237 cases (15 %) · ssm · crc_msk_2026 · largest of 3 cohorts	—	—	Rectal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 60 / 417 cases (14 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Appendix Adenocarcinoma 35 / 273 cases (13 %) · ssm · appendiceal_msk_2022	—	—	Appendix Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 48 / 429 cases (11 %) · ssm · coad_tcga_gdc	—	—	Colon Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 33 / 341 cases (9.7 %) · ssm · egc_msk_2017 · largest of 2 cohorts	—	—	Gastroesophageal Junction Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinomasubtype 34 / 412 cases (8.3 %) · ssm · pancreas_ctdna_msk_2025 · largest of 8 cohorts	—	—	Pancreatic Adenocarcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 103 / 1,370 cases (7.5 %) · ssm · hcc_msk_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 38 / 527 cases (7.2 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

SMAD4 altered in cohorts of …ALTERED_INderived12 of 12

→ altered in cohorts of

Esophageal Carcinoma

128 / 185 cases (69 %) · ssm · TCGA-ESCA

—

Esophageal Carcinoma

Observed

gdc

graph →

→ altered in cohorts of

Gallbladder Carcinoma

52 / 244 cases (21 %) · ssm · gbc_mskcc_2022 · largest of 2 cohorts